Biogenic Synthesis of Photosensitive Magnesium Oxide Nanoparticles Using Citron Waste Peel Extract and Evaluation of Their Antibacterial and Anticarcinogenic Potential

• Published in: Bioinorganic chemistry and applications 2024-06, Vol.2024, p.8180102
• Main Authors: Al Musayeib, Nawal M, Amina, Musarat, Maqsood, Farah, Bokhary, Kholoud A, Alrashidi, Nada S
• Format: Article
• Language: English
• Subjects: Analysis; Anticancer properties; Antiinfectives and antibacterials; Biocompatibility; Cancer; Cell membranes; Citrus; Citrus fruits; Dyes; E coli; Fruits; Green technology; Hazardous materials; Hazardous substances; Low concentrations; Magnesium oxide; Nanomaterials; Nanoparticles; Penicillin G; Performance degradation; Photodegradation; Photosensitivity; Reducing agents; Seeds; Superconductors (materials); Tetracycline; Tetracyclines; Ultraviolet radiation
• ISSN: 1565-3633; 1687-479X
• DOI: 10.1155/2024/8180102

Magnesium oxide nanoparticles (MgONPs) have been fabricated by several approaches, including green chemistry approach due to diverse application and versatile features. The current study aimed to prepare a convenient, biocompatible, and economically viable MgONPs using waste citron peel extract (CP-MgONPs) to evaluate their biological applications. The CP-MgONPs were synthesized by a sustainable approach from extract of waste citron peel both as capping and reducing agents without use of any hazardous material. The physicochemical features of formed CP-MgONPs were determined by sophisticated analytical and microscopic techniques. The biogenic CP-MgONPs were examined for their antibacterial, anticarcinogenic, and photocatalytic attributes. A prominent absorption peak in the UV-Vis spectra at 284 nm was the distinguishing characteristic of the CP-MgONPs. The scanning electron microscopy (SEM) reveals polyhedral morphology of nanoparticles with slight agglomeration of CP-MgONPs. The CP-MgONPs exerted excellent antibacterial potencies against six bacterial strains. The CP-MgONPs displayed significant susceptibility towards (20.72 ± 0.33 mm) and (19.52 ± 0.05 mm) with the highest inhibition zones. The anticancer effect of CP-MgONPs was evaluated against HepG2 (IC  : 15.3  g·mL ) cancer cells and exhibited potential anticancer activity. A prompt inversion of cellular injury manifested as impairment of the integrity of the cell membrane, apoptosis, and oxidative stress was observed in treated cells with CP-MgONPs. The biosynthesized CP-MgONPs also conducted successful photocatalytic potential as much as MgO powder under the UV-light using acid orange 8 (AO-8) dye. The degradation performance of CP-MgONPs showed over 94% photocatalytic degradation efficiency of acid orange 8 (AO-8) dyes within a short time. Outcomes of this research signify that biogenic CP-MgONPs may be advantageous at low concentrations, with positive environmental impacts.