Significance of nitrosative stress and glycoxidation products in the diagnosis of COVID-19

Nitrosative stress promotes protein glycoxidation, and both processes can occur during an infection with the SARS-CoV-2 virus. Therefore, the aim of this study was to assess selected nitrosative stress parameters and protein glycoxidation products in COVID-19 patients and convalescents relative to h...

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Bibliographic Details
Published in:Scientific reports 2024-04, Vol.14 (1), p.9198-9198, Article 9198
Main Authors: Wolszczak-Biedrzycka, Blanka, Dorf, Justyna, Matowicka-Karna, Joanna, Wojewódzka-Żeleźniakowicz, Marzena, Żukowski, Piotr, Zalewska, Anna, Maciejczyk, Mateusz
Format: Article
Language:English
Subjects:
631/250
631/80
Adult
Aged
Biomarkers
Biomarkers - blood
Colorimetry
COVID-19
COVID-19 - blood
COVID-19 - diagnosis
COVID-19 - metabolism
Female
Glycation End Products, Advanced - blood
Glycation End Products, Advanced - metabolism
Glycoxidation products
Humanities and Social Sciences
Humans
Kynurenine - analogs & derivatives
Kynurenine - blood
Kynurenine - metabolism
Male
MEWS
Middle Aged
multidisciplinary
Nitric Oxide - blood
Nitric Oxide - metabolism
Nitrosative Stress
Nitrotyrosine
Proteins
ROC Curve
S-Nitrosothiols - blood
S-Nitrosothiols - metabolism
SARS-CoV-2
SARS-CoV-2 virus
Science
Science (multidisciplinary)
Severe acute respiratory syndrome coronavirus 2
Tryptophan
Tryptophan - analogs & derivatives
Tryptophan - blood
Tryptophan - metabolism
Tyrosine - analogs & derivatives
Tyrosine - blood
Tyrosine - metabolism
Viruses
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Summary:Nitrosative stress promotes protein glycoxidation, and both processes can occur during an infection with the SARS-CoV-2 virus. Therefore, the aim of this study was to assess selected nitrosative stress parameters and protein glycoxidation products in COVID-19 patients and convalescents relative to healthy subjects, including in reference to the severity of COVID-19 symptoms. The diagnostic utility of nitrosative stress and protein glycoxidation biomarkers was also evaluated in COVID-19 patients. The study involved 218 patients with COVID-19, 69 convalescents, and 48 healthy subjects. Nitrosative stress parameters (NO, S-nitrosothiols, nitrotyrosine) and protein glycoxidation products (tryptophan, kynurenine, N-formylkynurenine, dityrosine, AGEs) were measured in the blood plasma or serum with the use of colorimetric/fluorometric methods. The levels of NO ( p  = 0.0480), S-nitrosothiols ( p  = 0.0004), nitrotyrosine ( p  = 0.0175), kynurenine ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-59876-w