PPAR Gamma and Angiogenesis: Endothelial Cells Perspective

We summarize the current knowledge concerning PPARγ function in angiogenesis. We discuss the mechanisms of action for PPARγ and its role in vasculature development and homeostasis, focusing on endothelial cells, endothelial progenitor cells, and bone marrow-derived proangiogenic cells.

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Bibliographic Details
Published in:Journal of diabetes research 2016-01, Vol.2016 (2016), p.1-11
Main Authors: Kotlinowski, Jerzy, Józkowicz, Alicja
Format: Article
Language:English
Subjects:
Adipocytes
Angiogenesis
Animals
Bone marrow
Bone Marrow Cells - cytology
Cardiovascular system
Cell Movement
Cytokines
Embryos
Endothelial Cells - cytology
Gene expression
Homeostasis
Humans
Ischemia
Ligands
Mice
Mice, Knockout
Neovascularization, Pathologic
Nitric oxide
Physiology
PPAR gamma - metabolism
PPAR gamma - physiology
Review
Stem Cells - cytology
Transcription Factors - metabolism
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - metabolism
Wound healing
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Description
Summary:We summarize the current knowledge concerning PPARγ function in angiogenesis. We discuss the mechanisms of action for PPARγ and its role in vasculature development and homeostasis, focusing on endothelial cells, endothelial progenitor cells, and bone marrow-derived proangiogenic cells.
ISSN:2314-6745
2314-6753
DOI:10.1155/2016/8492353