MMP-9 Levels in the Gingival Crevicular Fluid of Chilean Rosacea Patients

Rosacea is a chronic inflammatory skin disease whose prevalence rates remain unknown in Chile. Laboratory benchmark testing for this disease is not useful, therefore, we aimed to evaluate the gingival crevicular fluid (GCF) levels of extracellular metalloproteinases (MMP)-2 and MMP-9 as novel rosace...

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Published in:International journal of molecular sciences 2022-08, Vol.23 (17), p.9858
Main Authors: Fernández, Javier, Jiménez, Constanza, Benadof, Dafna, Morales, Paulina, Astorga, Jessica, Cáceres, Felipe, Hernández, Marcela, Fernández, Alejandra, Valenzuela, Fernando
Format: Article
Language:English
Subjects:
Acne
Adult
Biomarkers
Biomarkers - analysis
Body fluids
Chile
Chronic illnesses
Cross-Sectional Studies
Cytokines
Dermatitis
Diagnosis
Erythema
Evaluation
Gelatinase A
Gelatinase B
Gingiva
Gingival Crevicular Fluid
Humans
Laboratories
Matrix Metalloproteinase 9
Matrix metalloproteinases
Pathogenesis
Peptides
Periodontitis
Proteins
Psoriasis
Radiation
Rosacea
Rosacea - diagnosis
Skin diseases
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Summary:Rosacea is a chronic inflammatory skin disease whose prevalence rates remain unknown in Chile. Laboratory benchmark testing for this disease is not useful, therefore, we aimed to evaluate the gingival crevicular fluid (GCF) levels of extracellular metalloproteinases (MMP)-2 and MMP-9 as novel rosacea biomarkers. We designed a cross-sectional study with a control group. Participants were systemically healthy adults (n = 20) and persons with rosacea (n = 18). We performed a periodontal evaluation and collected gingival crevicular fluid to measure MMP-2 and MMP-9 levels. Analysis showed mean and standard deviation of MMP-9 concentrations in the GCF for patients with rosacea was 764.52 ± 569.83 pg/mL; for healthy patients, it was 260.69 ± 170.43 pg/mL (p < 0.05). The diagnosis of rosacea was responsible for the levels of MMP-9 in the GCF (p < 0.05), as opposed to periodontitis, smoking, and age (p > 0.05). The Area under ROC for MMP-9 was 0.869 (95%, C.I: 0.719−0.956), with a sensitivity of 72.22% and specificity of 81.58% for the diagnosis of rosacea. We conclude that the quantification of MMP-9 in the GCF could be used as a biomarker of rosacea. Also, rosacea was responsible for increasing the levels of MMP-9 in the GCF independent of periodontal status.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23179858