The Preventive Role of the Vitamin D Endocrine System in Cervical Cancer

Vitamin D along with its active metabolite calcitriol and its metabolic and signaling system, known as the vitamin D endocrine system, have been widely recognized as a pivotal regulator of calcium homeostasis in addition to non-calcemic antitumoral effects in a variety of human cancers, including ce...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-05, Vol.24 (10), p.8665
Main Authors: Avila, Euclides, Noriega-Mejía, Bryan Javier, González-Macías, Jocelyn, Cortes-Hernández, Ulises, García-Quiroz, Janice, García-Becerra, Rocío, Díaz, Lorenza
Format: Article
Language:English
Subjects:
Alfacalcidol
Apoptosis
B cells
Calcifediol
Calciferol
Calcitriol
Calcium homeostasis
Cancer
Cancer therapies
Cell proliferation
Cervical cancer
Cervix
Cervix Uteri - pathology
Chemotherapy
Development and progression
Endocrine system
Enzymes
Female
Gene expression
Homeostasis
Human papillomavirus
Humans
Infections
Inflammation
Lesions
LSIL
Metabolites
Oncology, Experimental
Ovarian cancer
Papillomaviridae
Papillomavirus infections
Papillomavirus Infections - pathology
Prevention
Review
Transcription factors
Uterine Cervical Dysplasia - pathology
Uterine Cervical Neoplasms - drug therapy
Uterine Cervical Neoplasms - epidemiology
Uterine Cervical Neoplasms - prevention & control
Viral infections
Vitamin D
Vitamin D - therapeutic use
Vitamin deficiency
Vitamins
women
Womens health
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Summary:Vitamin D along with its active metabolite calcitriol and its metabolic and signaling system, known as the vitamin D endocrine system, have been widely recognized as a pivotal regulator of calcium homeostasis in addition to non-calcemic antitumoral effects in a variety of human cancers, including cervical cancer. Several studies have found an inverse relationship between the incidence of cervical neoplasia and vitamin D levels. This narrative review updates the current evidence supporting the notion that the vitamin D endocrine system has a preventive role on cervical cancer, mainly in the early phases of the disease, acting at the level of suppressing cell proliferation, promoting apoptosis, modulating inflammatory responses, and probably favoring the clearance of human papillomavirus-dependent cervical lesions. Although an optimal vitamin D status helps in the prevention and regression of low-grade squamous intraepithelial lesions of the cervix, it appears that vitamin D alone or combined with chemotherapeutic agents has little effectivity once advanced cervical cancer is established. These observations suggest that an optimal vitamin D status might exert beneficial actions in the early phases of cervical cancer by preventing its onset and progression.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24108665