Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines

Condensation of 2-acetylnaphthalene with benzaldehydes under microwave irradiation affords chalcones which undergo facile and clean cyclizations with hydrazines RNHNH2 (R= H, Ph, Ac) to afford 3,5-arylated 2-pyrazolines in quantitative yields, also under microwave irradiation and in the presence of...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2003-07, Vol.8 (8), p.642-648
Main Authors: Azarifar, Davood, Ghasemnejad, Hassan
Format: Article
Language:English
Subjects:
5-arylated-2-pyrazolines
chalcones
heterocyclic synthesis
Microwave heating
Microwave irradiation
Pallets
pyrazolines
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Summary:Condensation of 2-acetylnaphthalene with benzaldehydes under microwave irradiation affords chalcones which undergo facile and clean cyclizations with hydrazines RNHNH2 (R= H, Ph, Ac) to afford 3,5-arylated 2-pyrazolines in quantitative yields, also under microwave irradiation and in the presence of dry AcOH as cyclizing agent. The results obtained indicate that, unlike classical heating, microwave irradiation results in higher yields, shorter reaction times (2-12 min.) and cleaner reactions.
ISSN:1420-3049
1420-3049
DOI:10.3390/80800642