Biomarkers of Uremic Cardiotoxicity

Cardiovascular (CV) morbidity and mortality increase along with the progression of chronic kidney disease (CKD). The potential novel biomarkers of cardiotoxicity have been tested with the aim of the early detection of patients at high CV risk, and among them are markers of inflammation, oxidative st...

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Bibliographic Details
Published in:Toxins 2021-09, Vol.13 (9), p.639
Main Authors: Stopic, Bojan, Dragicevic, Sandra, Medic-Brkic, Branislava, Nikolic, Aleksandra, Stojanovic, Marko, Budisavljevic, Sreten, Dimkovic, Nada
Format: Article
Language:English
Subjects:
acute renal injury
Adult
Aged
Aged, 80 and over
Albumin
Angina pectoris
Biomarkers
Biomarkers - metabolism
Calcium
Calcium antagonists
Cardiotoxicity
Cardiotoxicity - complications
Cardiotoxicity - metabolism
Cardiovascular disease
Cardiovascular diseases
cardiovascular event
Comorbidity
Dialysis
Diameters
Disease prevention
Erythropoiesis
Female
Ferritin
Heart
Heart failure
Humans
Hypertrophy
Infant, Newborn
Inflammation
Injury analysis
Interleukin 18
Ischemia
Kidney diseases
Kidneys
Laboratories
Male
MicroRNAs
Middle Aged
miRNA
Morbidity
Mortality
Oxidative stress
Pathogenesis
Prospective Studies
Regression analysis
Risk analysis
Risk factors
Septum
Serbia
Serum albumin
Urea
Uremia - complications
Uremia - metabolism
Ventricle
Young Adult
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Summary:Cardiovascular (CV) morbidity and mortality increase along with the progression of chronic kidney disease (CKD). The potential novel biomarkers of cardiotoxicity have been tested with the aim of the early detection of patients at high CV risk, and among them are markers of inflammation, oxidative stress, acute renal injury, and microRNAs. The study analyzed biomarkers in non-dialysis-dependent (NDD; stage 3a-4 CKD) and dialysis-dependent (DD) CKD patients. The prospective cohort study included 87 patients who were followed for 18 months, during which period newly occurred CV events were recorded. Cox regression analysis confirmed serum albumin, urea, interventricular septum thickness diameter (IVST), the use of calcium antagonist, and erythropoiesis-stimulating agent to be significant predictors of CV outcome. No significant difference was observed in biomarkers of inflammation, oxidative stress, acute kidney injury (IL-18, CRP, ferritin, IMA, SOD, NGAL, and KIM-1), and miR-133a, in regards to the presence/absence of CV event, CV death, and left ventricular hypertrophy. Serum albumin, urea, IVST, and the use of calcium antagonist and erythropoiesis-stimulating agents were confirmed to be factors associated with CV events in CKD patients. Apart from traditional risk factors, new research is needed to define novel and reliable biomarkers of cardiotoxicity in CKD patients.
ISSN:2072-6651
2072-6651
DOI:10.3390/toxins13090639