Secondary household transmission of SARS-CoV-2: a case-control study on factors associated with reduced transmission risk

•A case-control study was conducted to identify preventive factors of transmission.•Infection in the last 6 months was the most protective factor against transmission.•Home isolation of positive cohabitants related to lower transmission risk.•Old age groups of index cases related to low transmission...

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Bibliographic Details
Published in:International journal of infectious diseases 2023-12, Vol.137, p.4-8
Main Authors: Inaba, Masato, Miyake, Yukiko, Yasuda, Kazutaka
Format: Article
Language:English
Subjects:
COVID-19
History of SARS-CoV-2 infection
Home isolation
Household transmission
Omicron-targeting vaccine
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Summary:•A case-control study was conducted to identify preventive factors of transmission.•Infection in the last 6 months was the most protective factor against transmission.•Home isolation of positive cohabitants related to lower transmission risk.•Old age groups of index cases related to low transmission risk.•Booster shots exhibited protection; a small sample lacked significance. This study aimed to identify factors deterring secondary household transmission of SARS-CoV-2 from SARS-CoV-2-positive cohabitants. A case-control study was conducted with 272 healthcare workers in close contact with SARS-CoV-2-positive cohabitants. Logistic regression modeling was employed to determine the factors independently associated with secondary household transmission. A SARS-CoV-2 infection within the past 6 months was the most protective factor against secondary household transmission (adjusted odds ratio = 0.07, 95% CI: 0.01-0.61, P
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2023.09.019