Risk Stratification in Paragangliomas with PASS (Pheochromocytoma of the Adrenal Gland Scaled Score) and Immunohistochemical Markers

• Published in: Journal of clinical and diagnostic research 2016-09, Vol.10 (9), p.EC01-EC04
• Main Authors: Kulkarni, Maithili Mandar, Khandeparkar, Siddhi Gaurish Sinai, Deshmukh, Sanjay D, Karekar, R R, Gaopande, Vandana L, Joshi, Avinash R, Kesari, Mrunal V, Shelke, R R
• Format: Article
• Language: English
• Subjects: paraganglioma; pass score pheochromocytoma; Pathology Section; s100 immunoreactivity
• ISSN: 2249-782X; 0973-709X
• DOI: 10.7860/JCDR/2016/20565.8419

Paragangliomas (PGLs) are rare tumours that arise in sympathetic and parasympathetic paraganglia and are derived from neural crest cells. Presence of metastasis is the only absolute criterion for malignancy. There is no single histo-morphological feature indicating malignant potential and multiple parameters have been proposed to prognosticate the individual case. This includes studies conducted using Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) and Immunohistochemical (IHC) markers. We have studied ten cases of paraganglioma and attempted to correlate the prognosis with multiple clinicopathological variables. This study was done in a tertiary care general hospital over a period of five years. Available clinical records and histopathology slides of all patients were reviewed. Using Pheochromocytoma of the Adrenal Gland Scaled Score (PASS), we divided the cases into two groups-tumours showing high risk behaviour (PASS≥4) and tumours showing benign behaviour (PASS