Editorial: Disease-on-a-chip: from point-of-care to personalized medicine

• Published in: Frontiers in pharmacology 2023-12, Vol.14, p.1344379-1344379
• Main Authors: Cruz, Andrea, Fernandes, Elisabete, Rodrigues, Raquel Oliveira, Catarino, Susana Oliveira, Pinho, Diana
• Format: Article
• Language: English
• Subjects: Biotecnologia Médica; Ciências Médicas; Detection systems; Digital pills; drug-device; lab-on-chip; Microfluidic devices; Miniaturization; organ-on-chip; Pharmacology; Saúde de qualidade
• ISSN: 1663-9812; 1663-9812
• DOI: 10.3389/fphar.2023.1344379

[Excerpt] Introduction Miniaturization has played a pivotal role in driving innovation in microfluidic devices, particularly in their application across advanced technologies, such as Lab-on-chip platforms, Point-of-care systems, Organ-, Body- and Disease-on-a-chip technology. The personalized nature inherent in these systems, coupled with physiologically relevant readouts, opens novel avenues for individualized disease diagnostics, Figure 1. Additionally, they offer personalized strategies for assessing treatment efficacy and safety. Furthermore, the advancement in micro- and nano-microfluidic fabrication allows parallel analysis of large samples sets and the evaluation of different parameters such as biological molecules, cells or drugs.[...] The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The authors declare financial support: AC and EF are supported by the Lifesaver project funded by the European Union´s Horizon 2020 Research and Innovation Programme under the Grant agreement number 101036702; DP, SC, and RR thanks to Foundation for Science and Technology (FCT) for the contract funding provided through 2021.00027.CEECIND, 2020.00215.CEECIND and 2020.03975.CEECIND, respectively.