Role of Body Composition in Patients with Resectable Pancreatic Cancer

This study investigates the role of body composition parameters in patients with pancreatic cancer undergoing surgical treatment. The research involved 88 patients diagnosed with pancreatic cancer who underwent surgery at the Modena Cancer Center between June 2015 and October 2023. Body composition...

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Bibliographic Details
Published in:Nutrients 2024-06, Vol.16 (12), p.1834
Main Authors: Pecchi, Annarita, Valoriani, Filippo, Cuoghi Costantini, Riccardo, Squecco, Denise, Spallanzani, Andrea, D'Amico, Roberto, Dominici, Massimo, Di Benedetto, Fabrizio, Torricelli, Pietro, Menozzi, Renata
Format: Article
Language:English
Subjects:
Abdomen
Adipose Tissue
Aged
Body Composition
Body fat
Cancer
Cancer patients
Chemotherapy
Female
Humans
Male
Medical imaging
Medical prognosis
Middle Aged
Mortality
Musculoskeletal system
nutritional status
Oncology, Experimental
Pancreatic cancer
Pancreatic Neoplasms - mortality
Pancreatic Neoplasms - surgery
pancreatic surgery
Patients
Physiological aspects
Prognosis
Sarcopenia
Software
Surgery
Surgical outcomes
Tomography, X-Ray Computed
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Summary:This study investigates the role of body composition parameters in patients with pancreatic cancer undergoing surgical treatment. The research involved 88 patients diagnosed with pancreatic cancer who underwent surgery at the Modena Cancer Center between June 2015 and October 2023. Body composition parameters were obtained from CT scans performed before and after surgery. The percentage of sarcopenic patients at the time of diagnosis of pancreatic cancer is 56.82%. Of the patients who died between the first and second CT evaluated, 58% were sarcopenic, thus confirming the role of sarcopenia on outcome. The study found that all body composition parameters (TAMA, SMI, VFI, and SFI) demonstrated a trend towards reduction between two examinations, indicating an overall depletion in muscle and adipose tissue. We then evaluated the relationships between fat-related parameters (VFI, SFI and VSR) and survival outcomes: overall survival and progression-free survival. Cox univariate regression model show significant parameter related to outcomes was adipose tissue, specifically VFI. The study found that higher VFI levels were associated with greater survival rates. This research holds promise for advancing our understanding of the link between body composition and the prognosis of pancreatic cancer patients.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu16121834