Arterial Age and Early Vascular Aging, But Not Chronological Age, Are Associated With Faster Thoracic Aortic Aneurysm Growth

• Published in: Journal of the American Heart Association 2023-08, Vol.12 (16), p.e029466-e029466
• Main Authors: Mian, Owais, Santi, Nicolas, Boodhwani, Munir, Beauchesne, Luc, Chan, Kwan-Leung, Dennie, Carole, Wells, George A, Coutinho, Thais
• Format: Article
• Language: English
• Subjects: aortic aneurysm; aortic stiffness; arterial age; arterial stiffness; early vascular aging; hemodynamics; Original Research
• ISSN: 2047-9980; 2047-9980
• DOI: 10.1161/JAHA.122.029466

Background Aneurysm size is an imperfect risk assessment tool for those with thoracic aortic aneurysm (TAA). Assessing arterial age may help TAA risk stratification, as it better reflects aortic health. We sought to evaluate arterial age as a predictor of faster TAA growth, independently of chronological age. Methods and Results We examined 137 patients with TAA. Arterial age was estimated according to validated equations, using patients' blood pressure and carotid-femoral pulse wave velocity. Aneurysm growth was determined prospectively from available imaging studies. Multivariable linear regression assessed the association of chronological age and arterial age with TAA growth, and multivariable logistic regression assessed associations of chronological and arterial age with the presence of accelerated aneurysm growth (defined as growth>median in the sample). Mean±SD chronological and arterial ages were 62.2±11.3 and 54.2±24.5 years, respectively. Mean baseline TAA size and follow-up time were 45.9±4.0 mm and 4.5±1.9 years, respectively. Median (interquartile range) TAA growth was 0.31 (0.14-0.52) mm/year. Older arterial age (ß±SE for 1 year: 0.004±0.001,