Fibroblast Growth Factors in Depression

Major depressive disorder (MDD) is one of the most serious diseases and now becomes a major public health problem in the world. The pathogenesis of depression remains poorly understood. Fibroblast growth factors (FGFs) belong to a large family of growth factors that are involved in brain development...

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Published in:Frontiers in pharmacology 2019-02, Vol.10, p.60-60
Main Authors: Deng, Zheng, Deng, Sheng, Zhang, Mu-Rong, Tang, Mi-Mi
Format: Article
Language:English
Subjects:
depression
fibroblast growth factor
fibroblast growth factor receptor
hippocampus
major depressive disorder
Pharmacology
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description Major depressive disorder (MDD) is one of the most serious diseases and now becomes a major public health problem in the world. The pathogenesis of depression remains poorly understood. Fibroblast growth factors (FGFs) belong to a large family of growth factors that are involved in brain development during early periods as well as maintenance and repair throughout adulthood. In recent years, studies have found a correlation between the members of the FGF system and depression. These signaling molecules may be expected to be biomarkers for the diagnosis and prognosis of MDD, and may provide new drug targets for the treatment of depression. Here, we reviewed the correlation between some members of the FGF system and depression.
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subjects depression
fibroblast growth factor
fibroblast growth factor receptor
hippocampus
major depressive disorder
Pharmacology
title Fibroblast Growth Factors in Depression
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