Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders

Ensuring mitochondrial quality is essential for maintaining neuronal homeostasis, and mitochondrial transport plays a vital role in mitochondrial quality control. In this review, we first provide an overview of neuronal mitochondrial transport, followed by a detailed description of the various motor...

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Bibliographic Details
Published in:Frontiers in neuroscience 2023-10, Vol.17, p.1268883-1268883
Main Authors: Lu, Dengfeng, Feng, Yun, Liu, Guangjie, Yang, Yayi, Ren, Yubo, Chen, Zhouqing, Sun, Xiaoou, Guan, Yixiang, Wang, Zhong
Format: Article
Language:English
Subjects:
acute neurological disorders
Adapter proteins
Anterograde transport
Autophagy
Axonal transport
Cytoskeleton
dynein
Hemorrhage
Homeostasis
Ischemia
kinesin
Metabolism
miro
Mitochondria
Motility
Mutation
myosin
Neurological diseases
Neurological disorders
Neurons
Neuroscience
Quality control
Retrograde transport
Roads & highways
Spinal cord injuries
TRAK
Traumatic brain injury
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Summary:Ensuring mitochondrial quality is essential for maintaining neuronal homeostasis, and mitochondrial transport plays a vital role in mitochondrial quality control. In this review, we first provide an overview of neuronal mitochondrial transport, followed by a detailed description of the various motors and adaptors associated with the anterograde and retrograde transport of mitochondria. Subsequently, we review the modest evidence involving mitochondrial transport mechanisms that has surfaced in acute neurological disorders, including traumatic brain injury, spinal cord injury, spontaneous intracerebral hemorrhage, and ischemic stroke. An in-depth study of this area will help deepen our understanding of the mechanisms underlying the development of various acute neurological disorders and ultimately improve therapeutic options.
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2023.1268883