DBS in Treatment of Post-Traumatic Stress Disorder

Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition for which pharmacological therapy is not always solvable. Various treatments have been suggested and deep brain stimulation (DBS) is currently under investigation for patients affected by PTSD. We review the neurocircuitry...

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Bibliographic Details
Published in:Brain sciences 2018-01, Vol.8 (1), p.18
Main Authors: Lavano, Angelo, Guzzi, Giusy, Della Torre, Attilio, Lavano, Serena Marianna, Tiriolo, Raffaele, Volpentesta, Giorgio
Format: Article
Language:English
Subjects:
amygdala
Brain
Deep brain stimulation
fear extinction
Post traumatic stress disorder
posttraumatic stress disorder
prefrontal cortex
Review
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Summary:Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition for which pharmacological therapy is not always solvable. Various treatments have been suggested and deep brain stimulation (DBS) is currently under investigation for patients affected by PTSD. We review the neurocircuitry and up-to-date clinical concepts which are behind the use of DBS in posttraumatic stress disorder (PTSD). The role of DBS in treatment-refractory PTSD patients has been investigated relying on both preclinical and clinical studies. DBS for PTSD is in its preliminary phases and likely to provide hope for patients with medical refractory PTSD following the results of randomized controlled studies.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci8010018