Influence of Cultivation Conditions on the Sioxanthin Content and Antioxidative Protection Effect of a Crude Extract from the Vegetative Mycelium of Salinispora tropica

Due to their bioavailability, glycosylated carotenoids may have interesting biological effects. Sioxanthin, as a representative of this type of carotenoid, has been identified in marine actinomycetes of the genus . This study evaluates, for the first time, the effect of cultivation temperature (T) a...

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Bibliographic Details
Published in:Marine drugs 2021-09, Vol.19 (9), p.509
Main Authors: Jezkova, Zuzana, Schulzova, Vera, Krizova, Ivana, Karabin, Marcel, Branyik, Tomas
Format: Article
Language:English
Subjects:
Actinomycetes
Animals
antioxidant activity
Antioxidants
Antioxidants - chemistry
Antioxidants - pharmacology
Aquatic Organisms
Bioavailability
Biological effects
Biomass
Biphenyl Compounds
Carotenoids
Carotenoids - metabolism
Carotenoids - pharmacology
Cell Line - drug effects
Cell lines
Complex Mixtures
Cultivation
Cytotoxicity
Free radicals
Humans
Identification
Light
Light intensity
Luminous intensity
Micromonosporaceae
Microorganisms
Mycelium
Oxidative stress
Oxidative Stress - drug effects
Picrates
Regression analysis
Salinispora tropica
sioxanthin
Temperature
total cellular carotenoids
Toxicity
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Summary:Due to their bioavailability, glycosylated carotenoids may have interesting biological effects. Sioxanthin, as a representative of this type of carotenoid, has been identified in marine actinomycetes of the genus . This study evaluates, for the first time, the effect of cultivation temperature (T) and light intensity (LI) on the total cellular carotenoid content (TC), antioxidant activity (AA) and sioxanthin content (SX) of a crude extract (CE) from biomass in its vegetative state. Treatment-related differences in TC and SX values were statistically significantly and positively affected by T and LI, while AA was most significantly affected by T. In the CE, TC correlated well (R = 0.823) with SX and somewhat less with AA (R = 0.777). A correlation between AA and SX was found to be less significant (R = 0.731). The most significant protective effect against oxidative stress was identified in the CE extracted from biomass grown at the highest T and LI (CE-C), as was demonstrated using LNCaP and KYSE-30 human cell lines. The CE showed no cytotoxicity against LNCaP and KYSE-30 cell lines.
ISSN:1660-3397
1660-3397
DOI:10.3390/MD19090509