Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach

We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 virus were investigated and their cytotoxicity was also determined. Among all the synthesized conjugates, compound 9f showed...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-09, Vol.27 (18), p.5923
Main Authors: Wyman, Kailey A, Girgis, Adel S, Surapaneni, Pragnakiran S, Moore, Jade M, Abo Shama, Noura M, Mahmoud, Sara H, Mostafa, Ahmed, Barghash, Reham F, Juan, Zou, Dobaria, Radha D, Almalki, Ahmad J, Ibrahim, Tarek S, Panda, Siva S
Format: Article
Language:English
Subjects:
Antiviral activity
Antiviral agents
Chromatography
Computer applications
Conjugates
Cytotoxicity
Delavirdine
Drug resistance
Fluorine
Health aspects
healthcare
Hybridization
indole
Instrument industry
molecular modeling
quinoline
rhodanine
SARS-CoV-2
Selectivity
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Vaccines
Viruses
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Summary:We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 virus were investigated and their cytotoxicity was also determined. Among all the synthesized conjugates, compound 9f showed potential against SARS-CoV-2 and low cytotoxicity. The conjugates’ selectivity indexes (SIs) were determined to correlate the antiviral properties and cytotoxicity. The observed biological data were further validated using computational studies.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27185923