Possible relevance of receptor-receptor interactions between viral- and host-coded receptors for viral-induced disease

It has been demonstrated that some viruses, such as the cytomegalovirus, code for G-protein coupled receptors not only to elude the immune system, but also to redirect cellular signaling in the receptor networks of the host cells. In view of the existence of receptor-receptor interactions, the hypot...

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Bibliographic Details
Published in:TheScientificWorld 2007-01, Vol.7, p.1073-1081
Main Authors: Agnati, Luigi F, Leo, Giuseppina, Genedani, Susanna, Guidolin, Diego, Andreoli, Nicola, Fuxe, Kjell
Format: Article
Language:English
Subjects:
Cytomegalovirus
Medicin och hälsovetenskap
Receptors, G-Protein-Coupled - metabolism
Review
Signal Transduction
Virus Activation - physiology
Virus Diseases - metabolism
Viruses - metabolism
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Summary:It has been demonstrated that some viruses, such as the cytomegalovirus, code for G-protein coupled receptors not only to elude the immune system, but also to redirect cellular signaling in the receptor networks of the host cells. In view of the existence of receptor-receptor interactions, the hypothesis is introduced that these viral-coded receptors not only operate as constitutively active monomers, but also can affect other receptor function by interacting with receptors of the host cell. Furthermore, it is suggested that viruses could also insert not single receptors (monomers), but clusters of receptors (receptor mosaics), altering the cell metabolism in a profound way. The prevention of viral receptor-induced changes in host receptor networks may give rise to novel antiviral drugs that counteract viral-induced disease.
ISSN:1537-744X
2356-6140
1537-744X
DOI:10.1100/tsw.2007.166