Novel gas mixture combined with an auto-transfusion tourniquet enhances cerebral O2 transport and hemodynamic indices in CPR swine. Part B – A pilot experimental study

The cognitive outcome of CPR is poor. This study aims to evaluate if enhancing blood flow to the brain and oxygen dissociation from the hemoglobin improve cerebral O2 transport during CPR in cardiac arrest swine. Standard swine-CPR model of induced VF and recovery was treated with an auto-transfusio...

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Bibliographic Details
Published in:Resuscitation plus 2024-09, Vol.19, p.100681, Article 100681
Main Authors: Gavriely, Noam, Rasanen, Jukka O, Saar, Sharon Abadi, Lamhaut, Lionel, Hutin, Alice, Lidouren, Fanny, Abi Zeid Daou, Yara, Tissier, Renaud
Format: Article
Language:English
Subjects:
Cardiac Arrest
Cardio-pulmonary resuscitation
Cerebral oxygen delivery
COXAR
Experimental Paper
HemaShock
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Summary:The cognitive outcome of CPR is poor. This study aims to evaluate if enhancing blood flow to the brain and oxygen dissociation from the hemoglobin improve cerebral O2 transport during CPR in cardiac arrest swine. Standard swine-CPR model of induced VF and recovery was treated with an auto-transfusion tourniquet (A-TT®; HemaShock® (HS) Oneg HaKarmel Ltd. Israel) and ventilation with a novel mixture of 30% Oxygen, 5% CO2, and 65% Argon (COXAR™). Five swine received the study treatment and 5 controls standard therapy. Animals were anesthetized, ventilated, and instrumented for blood draws and pressure measurements. Five minutes of no-CPR arrest were followed by 10 min of mechanical CPR with and without COXAR-HS™ enhancement followed by defibrillation and 45 min post ROSC follow-up. All 5 COXAR-HS™ animals were resuscitated successfully as opposed to 3 of the control animals. Systolic (p 
ISSN:2666-5204
2666-5204
DOI:10.1016/j.resplu.2024.100681