Structure–activity relationships and interindividual variability of drug responses: pharmacogenomics with antimicrobial drugs as a paradigm

Adverse drug reactions represent a major health burden because they cause notable patient morbidity and mortality. From this viewpoint, several strategies have been developed to prevent or reduce adverse drug reactions. One such strategy is the use of pharmacogenomics. Interindividual variability in...

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Bibliographic Details
Published in:Journal of international medical research 2023-11, Vol.51 (11)
Main Authors: Thabet, Romany H., Alshar, Bayan Osama Shehadeh, Alabdallah, Doaa Habes Saleh, Alhmoud, Nour Alhuda Zaid Ahmad, Alslameen, Sondos Taher Abdalsalam, Thabet, Youssef Romany Helmy
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
Side effects
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Summary:Adverse drug reactions represent a major health burden because they cause notable patient morbidity and mortality. From this viewpoint, several strategies have been developed to prevent or reduce adverse drug reactions. One such strategy is the use of pharmacogenomics. Interindividual variability in drug response and adverse effects is mainly attributable to genetic variation in enzymes such as sulfotransferases and cytochrome P450s. The current narrative review discusses the relationship between the structure and activity of drugs. Specifically, the activity of drugs can be increased and/or their adverse effects can be reduced by altering specific positions in their structures.
ISSN:0300-0605
1473-2300
DOI:10.1177/03000605231214065