Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates

Plasmodium vivax control is now being hampered by drug resistance. Orthologous Plasmodium falciparum genes linked to chloroquine or sulfadoxine-pyrimethamine chemoresistance have been identified in P. vivax parasites, but few studies have been performed. The goal of the present work is to characteri...

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Published in:Memórias do Instituto Oswaldo Cruz 2009-11, Vol.104 (7), p.1009-1011
Main Authors: Gama, Bianca Ervatti, Oliveira, Natália Ketrin Almeida de, Souza, José Maria de, Daniel-Ribeiro, Cláudio Tadeu, Ferreira-da-Cruz, Maria de Fátima
Format: Article
Language:English
Subjects:
Animals
Brazil
chemoresistance
Genes, Protozoan - genetics
Humans
Insecticide Resistance - genetics
malaria
Malaria, Vivax - drug therapy
Malaria, Vivax - parasitology
Multidrug Resistance-Associated Proteins - genetics
Mutation - drug effects
Mutation - genetics
PARASITOLOGY
Plasmodium falciparum
Plasmodium vivax
Plasmodium vivax - drug effects
Plasmodium vivax - genetics
Polymorphism, Single Nucleotide
Protozoan Proteins - genetics
pvdhfr
pvmdr1
TROPICAL MEDICINE
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Summary:Plasmodium vivax control is now being hampered by drug resistance. Orthologous Plasmodium falciparum genes linked to chloroquine or sulfadoxine-pyrimethamine chemoresistance have been identified in P. vivax parasites, but few studies have been performed. The goal of the present work is to characterise pvmdr1 and pvdhfr genes in parasite isolates from a Brazilian endemic area where no molecular investigation had been previously conducted. The pvmdr1 analysis revealed the existence of single (85.7%) and double (14.3%) mutant haplotypes, while the pvdhfr examination showed the presence of double (57.2%) and triple (42.8%) mutant haplotypes. The implications of these findings are discussed.
ISSN:0074-0276
1678-8060
1678-8060
0074-0276
DOI:10.1590/S0074-02762009000700012