Bone mineral density and serum levels of 25 OH vitamin D in chronic users of antiepileptic drugs Densidade mineral óssea e níveis séricos de 25 OH vitamina D em usuários crônicos de drogas antiepilépticas

• Published in: Arquivos de neuro-psiquiatria 2004-12, Vol.62 (4), p.940-948
• Main Authors: Carolina A.M. Kulak, Victória Z.C. Borba, John P. Bilezikian, Carlos E. Silvado, Luciano de Paola, César L. Boguszewski
• Format: Article
• Language: English
• Subjects: 25OH vitamin D; 25OH vitamina D; drogas antiepiléticas indutoras hepáticas; Enzyme-inducing antiepileptic drugs; osteomalacia; osteomalácea
• ISSN: 0004-282X; 1678-4227
• DOI: 10.1590/S0004-282X2004000600003

The aim of this cross sectional study was to evaluate bone mineral density (BMD) and serum levels of 25-hydroxy vitamin D (25OHD) in a group of patients taking antiepileptic drugs (AED) for a seizure disorder. Between May-2001 and January-2003, we evaluated 58 patients (40 women/18 men), 34.4±6 years old living in Curitiba or in its metropolitan area, on antiepileptic therapy for 2 to 38 years (10 on monotherapy /48 on multiple drugs regime). The group was matched by age, gender, and bone mass index to 29 healthy subjects (20 women/ 9 men); 34.2±5.9 years old. Medical history and physical exam were performed on all subjects with particular information sought about fractures and risks factors for osteoporosis. Blood samples were collected for total serum calcium, albumin, phosphorus, creatinine, total alkaline phosphatase, and liver function tests. BMD of the lumbar spine, femur and forearm was determined by dual energy X-ray absorptiometry (DXA, Hologic QDR 1000). Between February and April-2003, other blood samples were collected to measure 25OHD, intact paratohormone (PTH) and calcium. Unemployment and smoking history were more frequent among patients than among controls (p