The Hepatoprotective Effect of Jaboticaba Peel Powder in a Rat Model of Type 2 Diabetes Mellitus Involves the Modulation of Thiol/Disulfide Redox State through the Upregulation of Glutathione Synthesis

Jaboticaba peel powder (JPP) is rich in bioactive compounds, mainly soluble and insoluble polyphenols with great antioxidant properties. The aim of this study is to evaluate the effects of JPP supplementation on the oxidative stress and hepatic damage in a rat model of type 2 diabetes mellitus (T2DM...

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Published in:Journal of nutrition and metabolism 2018-01, Vol.2018 (2018), p.1-13
Main Authors: Maróstica Júnior, Mário Roberto, Cruz, Ivana B. Mânica da, Emanuelli, Tatiana, Barbisan, Fernanda, Teixeira, Cibele F., Roehrs, Miguel, Somacal, Sabrina, Figueiredo, Cassieli Gehlen, Silva, Dariane Trivisiol da, Conte, Lisiane, Quatrin, Andréia, Augusti, Paula Rossini
Format: Article
Language:English
Subjects:
Antioxidants
Apoptosis
Aspartate aminotransferase
Atherosclerosis
Bioactive compounds
Biology
Calibration
Cardiovascular disease
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Drinking water
Dyslipidemia
Enzymes
Free radicals
Glutathione
Hyperglycemia
Hypertrophy
Insulin resistance
Lipids
Liver
Medicine
Metabolism
Oxidation
Oxidative stress
Polyphenols
Powder
Proteins
Redox properties
Rodents
Supplements
Thiols
Type 2 diabetes
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Summary:Jaboticaba peel powder (JPP) is rich in bioactive compounds, mainly soluble and insoluble polyphenols with great antioxidant properties. The aim of this study is to evaluate the effects of JPP supplementation on the oxidative stress and hepatic damage in a rat model of type 2 diabetes mellitus (T2DM). Diabetic rats received vehicle or JPP at 2.7 (JPP-I), 5.4 (JPP-II), or 10.8 (JPP-III) g/L in drinking water during 8 weeks. JPP-III attenuated hyperglycaemia and dyslipidemia increased by 86% the liver content of nonprotein thiol groups and by 90% the GSH/GSSG ratio by activating glutathione synthesis. Accordingly, JPP supplementation prevented the loss of activity of the sulfhydryl-dependent enzyme δ-aminolaevulinic acid dehydratase and attenuated hepatic injury assessed by the reduction of serum aspartate aminotransferase activity and liver hypertrophy. Our results support that JPP supplementation to T2DM rats decreases hepatic damage most likely by increasing glutathione synthesis and modulating the thiol/disulfide redox balance.
ISSN:2090-0724
2090-0732
DOI:10.1155/2018/9794629