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Molluscicidal Activity of Extracts and Fractions From Hagenia abyssinica , Rosa abyssinica , and Cucumis ficifolius Against Biomphalaria and Bulinus Snails
: Schistosomiasis continues to be a major public health concern in Ethiopia. Eliminating the intermediate host snails is an effective and cost-efficient strategy for preventing and controlling schistosomiasis transmission. However, chemical molluscicides have limitations due to their toxicity to non...
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Published in: | Journal of parasitology research 2024-11, Vol.2024 (1), p.7968654 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | : Schistosomiasis continues to be a major public health concern in Ethiopia. Eliminating the intermediate host snails is an effective and cost-efficient strategy for preventing and controlling schistosomiasis transmission. However, chemical molluscicides have limitations due to their toxicity to nontarget aquatic organisms, environmental concerns, and the development of resistance. Plant-based molluscicides are biodegradable, less toxic, safe, and cost-effective.
: This study is aimed at evaluating the molluscicidal activity of
flowers,
fruits, and
roots against
and
species.
: Adult
and
species were subjected to varying concentrations of aqueous and 70% ethanol extracts and solvent partitions from
,
, and
for 24, 48, and 72 h. The investigation involved conducting a phytochemical analysis using standard screening methods. Female mice were subjected to an acute oral toxicity test using a 70% ethanol extract of
,
, and
. The mortality data were then determined using GraphPad Prism 9 software.
: Aqueous and 70% ethanol extracts of
and
did not exhibit molluscicidal activities against
and
species. However, aqueous, 70% ethanol, and chloroform extracts of
showed significant molluscicidal activities against
species with 24-h LC
values of 39.05, 11.93, and 5.52 mg/L, respectively. Similarly, the LC
values of the same extracts against
species after 24 h of exposure were 40.08, 12.23, and 6.13 mg/L, respectively. The plant extract's LD
for acute toxicity against mice was found to be over 2000 mg/kg of body weight.
:
demonstrated potent molluscicidal activity, making it a potential candidate for application. Further isolation of active ingredients and field trials are necessary to determine the optimal conditions for its use in snail control. |
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ISSN: | 2090-0023 2090-0031 |
DOI: | 10.1155/japr/7968654 |