Fabricating the multibranch carboxyl-modified cellulose for hemorrhage control

• Published in: Materials today bio 2024-02, Vol.24, p.100878-100878, Article 100878
• Main Authors: Li, Shengyu, Gong, Lihong, Chen, Jianglin, Wu, Xijin, Liu, Xia, Fu, Huiying, Shou, Qiyang
• Format: Article
• Language: English
• Subjects: Biocompatibility; Hemorrhage control; Microcrystalline cellulose; Multibranch
• ISSN: 2590-0064; 2590-0064
• DOI: 10.1016/j.mtbio.2023.100878

Excessive bleeding is associated with a high mortality risk. In this study, citric acid and ascorbic acid were sequentially modified on the surface of microcrystalline cellulose (MCAA) to increase its carboxyl content, and their potential as hemostatic materials was investigated. The MCAA exhibited a carboxylic group content of 9.52 %, higher than that of citric acid grafted microcrystalline cellulose (MCA) at 4.6 %. Carboxyl functionalization of microcrystalline cellulose surfaces not only plays a fundamental role in the structure of composite materials but also aids in the absorption of plasma and stimulation of platelets. Fourier -transform infrared (FT-IR), thermogravimetric analysis (TGA) and X-ray photoelectron spectroscopy (XPS) spectra confirmed that carboxyl groups were successfully introduced onto the cellulose surface. Physical properties tests indicated that the MCAA possessed higher thermal stability (Tmax = 472.2 °C) compared to microcrystalline cellulose (MCC). Additionally, in vitro hemocompatibility, cytotoxicity and hemostatic property results demonstrated that MCAA displayed good biocompatibility (hemolysis ratio