Epigallocatechin Gallate (EGCG), a Green Tea Polyphenol, Reduces Coronavirus Replication in a Mouse Model

The COVID-19 pandemic has resulted in a huge number of deaths from 2020 to 2021; however, effective antiviral drugs against SARS-CoV-2 are currently under development. Recent studies have demonstrated that green tea polyphenols, particularly EGCG, inhibit coronavirus enzymes as well as coronavirus r...

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Bibliographic Details
Published in:Viruses 2021-12, Vol.13 (12), p.2533
Main Authors: Park, Rackhyun, Jang, Minsu, Park, Yea-In, Park, Yeonjeong, Jung, Woochul, Park, Jayhyun, Park, Junsoo
Format: Article
Language:English
Subjects:
Animals
Antiviral agents
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
Catechin
Catechin - analogs & derivatives
Catechin - pharmacology
Catechin - therapeutic use
Cell Line
coronavirus
Coronavirus Infections - drug therapy
Coronavirus Infections - virology
Coronavirus OC43, Human - drug effects
Coronavirus OC43, Human - physiology
Coronaviruses
COVID-19
Disease Models, Animal
Drug development
EGCG
Epigallocatechin gallate
Epigallocatechin-3-gallate
Green tea
HCoV-OC43
Humans
Mice
Pandemics
Polyphenols
Polyphenols - chemistry
Polyphenols - pharmacology
Polyphenols - therapeutic use
Replication
Scanning electron microscopy
Severe acute respiratory syndrome coronavirus 2
Tea
Tea - chemistry
Virions
Virus Replication - drug effects
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Summary:The COVID-19 pandemic has resulted in a huge number of deaths from 2020 to 2021; however, effective antiviral drugs against SARS-CoV-2 are currently under development. Recent studies have demonstrated that green tea polyphenols, particularly EGCG, inhibit coronavirus enzymes as well as coronavirus replication in vitro. Herein, we examined the inhibitory effect of green tea polyphenols on coronavirus replication in a mouse model. We used epigallocatechin gallate (EGCG) and green tea polyphenols containing more than 60% catechin (GTP60) and human coronavirus OC43 (HCoV-OC43) as a surrogate for SARS-CoV-2. Scanning electron microscopy analysis results showed that HCoV-OC43 infection resulted in virion particle production in infected cells. EGCG and GTP60 treatment reduced coronavirus protein and virus production in the cells. Finally, EGCG- and GTP60-fed mice exhibited reduced levels of coronavirus RNA in mouse lungs. These results demonstrate that green tea polyphenol treatment is effective in decreasing the level of coronavirus in vivo.
ISSN:1999-4915
1999-4915
DOI:10.3390/v13122533