Predictors of psychosocial outcome of bipolar disorder: data from the Stanley Foundation Bipolar Network

Background Impairments in psychosocial functioning have been demonstrated in 30–60% of adults with bipolar disorder (BD). However, the majority of studies investigating the effect of comorbid mental health disorders and age at onset outcomes in BD have focused on traditional outcome measures such as...

Full description

Saved in:
Bibliographic Details
Published in:International Journal of Bipolar Disorders 2019-12, Vol.7 (1), p.28-9, Article 28
Main Authors: Bennett, Francis, Hodgetts, Sophie, Close, Andrew, Frye, Mark, Grunze, Heinz, Keck, Paul, Kupka, Ralph, McElroy, Susan, Nolen, Willem, Post, Robert, Schärer, Lars, Suppes, Trisha, Sharma, Aditya N.
Format: Article
Language:English
Subjects:
Anxiety
Attention deficit hyperactivity disorder
Behavioral Therapy
Bipolar disorder
Clinical Psychology
Comorbidity
Medicine
Medicine & Public Health
Mental disorders
Mental health
Neurology
Psychiatry
Psychopharmacology
Psychotherapy
Social functioning
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Impairments in psychosocial functioning have been demonstrated in 30–60% of adults with bipolar disorder (BD). However, the majority of studies investigating the effect of comorbid mental health disorders and age at onset outcomes in BD have focused on traditional outcome measures such as mood symptoms, mortality and treatment response. Therefore, this project aimed to investigate the impact of comorbid mental health disorders and age at onset on longitudinal psychosocial outcome in participants with BD. Method Mixed effects modelling was conducted using data from the Stanley Foundation Bipolar Network. Baseline factors were entered into a model, with Global Assessment of Functioning (GAF) score as the longitudinal outcome measure. Relative model fits were calculated using Akaike’s Information Criterion. Results No individual comorbidities predicted lower GAF scores, however an interaction effect was demonstrated between attention deficit hyperactivity disorder (ADHD) and any anxiety disorder ( t  = 2.180, p  = 0.030). Participants with BD I vs BD II ( t  = 2.023, p  = 0.044) and those in the lowest vs. highest income class ( t  = 2.266, p  = 0.024) predicted lower GAF scores. Age at onset ( t  = 1.672, p  = 0.095) did not significantly predict GAF scores. Conclusions This is the first study to demonstrate the negative psychosocial effects of comorbid anxiety disorders and ADHD in BD. This study adds to the growing database suggesting that comorbid mental health disorders are a significant factor hindering psychosocial recovery.
ISSN:2194-7511
2194-7511
DOI:10.1186/s40345-019-0169-5