Lagerindicine, a New Pyrrole Alkaloid Isolated from the Flowers of Lagerstroemia indica Linnaeus

A phytochemical investigation of the EtOH extract of the flowers of Lagerstroemia indica L. led to the isolation and characterization of a new pyrrole alkaloid, named lagerindicine ( 1 ), along with four known compounds ( 2 – 5 ). Their structures were elucidated by the detailed spectroscopic analys...

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Bibliographic Details
Published in:Natural products and bioprospecting 2021-02, Vol.11 (1), p.73-79
Main Authors: Chen, Yi, Li, Song-Wei, Yin, Fang-Zhou, Yang, Min, Huan, Xia-Juan, Miao, Ze-Hong, Wang, Xiao-Ming, Guo, Yue-Wei
Format: Article
Language:English
Subjects:
Absolute configuration
Alkaloids
Biomedical and Life Sciences
Bioorganic Chemistry
Colon
Colon cancer
Cytotoxicity
Flowers
Food Science
Lagerstroemia indica
Lagerstroemia indica Linnaeus
Life Sciences
Medicinal Chemistry
Original
Original Article
Pharmacology/Toxicology
Plant Biochemistry
Plant Sciences
Pyrrole alkaloid
Stereochemistry
Total synthesis
Toxicity
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Summary:A phytochemical investigation of the EtOH extract of the flowers of Lagerstroemia indica L. led to the isolation and characterization of a new pyrrole alkaloid, named lagerindicine ( 1 ), along with four known compounds ( 2 – 5 ). Their structures were elucidated by the detailed spectroscopic analysis and comparison with literature data, whereas the structure, in particularly, the absolute configuration (AC) of 1 , was firmly determined by total synthesis. All the isolates were evaluated for their cytotoxic effects against human colon cancer cell (HCT-116), and compound 3 exhibited weak cytotoxicity with IC 50 value of 28.4 μM. Graphic Abstract
ISSN:2192-2195
2192-2209
DOI:10.1007/s13659-020-00273-x