Antidiabetic and gastric emptying inhibitory effect of herbal Melia azedarach leaf extract in rodent models of diabetes type 2 mellitus

Diabetes type 2 is associated with impaired insulin production and increased insulin resistance. Treatment with antidiabetic drugs and insulin strives for normalizing glucose homeostasis. In Ethiopian traditional medicine, plant extracts of are used to control diabetes mellitus and various gastroint...

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Bibliographic Details
Published in:Journal of experimental pharmacology 2017, Vol.9, p.23-29
Main Authors: Seifu, Daniel, Gustafsson, Lars E, Chawla, Rajinder, Genet, Solomon, Debella, Asfaw, Holst, Mikael, Hellström, Per M
Format: Article
Language:English
Subjects:
Abdomen
Analysis
Antidiabetics
Care and treatment
Diabetes
Experiments
Glucose
glucose tolerance test
goto-kakizaki
Hyperglycemia
Insulin resistance
Laboratory animals
Metabolism
Neem
Nutrition research
ob/ob mouse
Original Research
Patient outcomes
Peptides
Physiological aspects
Properties
Rodents
sprague-dawley
Treatment outcome
Type 2 diabetes
Veins & arteries
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Summary:Diabetes type 2 is associated with impaired insulin production and increased insulin resistance. Treatment with antidiabetic drugs and insulin strives for normalizing glucose homeostasis. In Ethiopian traditional medicine, plant extracts of are used to control diabetes mellitus and various gastrointestinal disorders. The objective of this study was to clarify the antidiabetic effects of leaf extracts in diabetic type 2 experimental animals. In this study, mice were injected with extract intraperitoneally. Plasma glucose was studied by using tail vein sampling in acute experiments over 4 h and chronic experiments over 21 days with concurrent insulin and body weight assessments. Glucose tolerance was studied by using intraperitoneal glucose (2 mg/g) tolerance test over 120 min. Gastric emptying of a metabolically inert meal was studied by the gastric retention of a radioactive marker over 20 min. extracts displayed acute, dose-dependent antidiabetic effects in ob/ob mice similar to glibenclamide (
ISSN:1179-1454
1179-1454
DOI:10.2147/JEP.S126146