Restless Legs Syndrome as a Comorbidity in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a multisystem disease with a complex immunologic pathophysiology. Likewise, sleep disorders can involve a complicated interplay between the neurologic pathways, immune system, and respiratory system. Recent studies have shown an elevated prevalence of sleep abnormalities...

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Bibliographic Details
Published in:Autoimmune Diseases 2013-01, Vol.2013 (2013), p.47-51
Main Authors: Gjevre, John A., Taylor Gjevre, Regina M.
Format: Article
Language:English
Subjects:
Brain research
Care and treatment
Connective tissues
Cytokines
Diagnosis
Eye movements
Health aspects
Immune system
Immunomodulation
Iron
Leg
Lupus
Muscle pain
Pathophysiology
Patients
Physiological aspects
Physiology
Quality of life
Respiratory system
Restless legs syndrome
Review
Rheumatic diseases
Rheumatoid arthritis
Scleroderma
Sleep
Sleep disorders
Tumor necrosis factor-α
Womens health
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Description
Summary:Rheumatoid arthritis (RA) is a multisystem disease with a complex immunologic pathophysiology. Likewise, sleep disorders can involve a complicated interplay between the neurologic pathways, immune system, and respiratory system. Recent studies have shown an elevated prevalence of sleep abnormalities in connective tissue disorders compared to the general population. Restless legs syndrome (RLS) may be present in up to 30% of RA patients. These findings may be related to cytokine release and other immunomodulatory responses. TNF-α levels relate to sleep physiology and anti-TNF-α therapy may improve sleep patterns. Most of the patients with this disorder can distinguish their RLS sensations from their arthritic symptoms. RLS is a common comorbidity seen with RA, and prompt recognition and treatment can improve patient quality of life.
ISSN:2090-0430
2090-0422
2090-0430
DOI:10.1155/2013/352782