Philadelphia chromosome positive chronic myeloid leukemia with 5q deletion at diagnosis

Although, molecular genetic analyses became more and more important to guide therapy decisions in leukemia, banding cytogenetic analysis has retained its vital role in diagnosis and monitoring of chronic myeloid leukemia (CML), by quick and easy enabling identification of pathognomonic Philadelphia...

Full description

Saved in:
Bibliographic Details
Published in:Molecular cytogenetics 2021-03, Vol.14 (1), p.16-16, Article 16
Main Authors: Haidary, Ahmed Maseh, Ahmed, Zeeshan Ansar, Abdul-Ghafar, Jamshid, Rahmani, Soma, Noor, Sarah, Erfani, Farahnaz, Ahmad, Maryam, Lakanwall, Naeem, Malakzai, Haider Ali, Ibrahimkhil, Abdul Sami, Esmat, Esmatullah, Haidari, Mujtaba, Yousufzai, Nimattullah, Sharif, Samuel, Saqib, Abdul Hadi
Format: Article
Language:English
Subjects:
5q deletion
Blood tests
Bone marrow
Cancer
Care and treatment
Case Report
Chromosome 5
Chromosome deletion
Chromosomes
Chronic myelogenous leukemia (CML)
Chronic myeloid leukemia
Cloning
Cytogenetics
Diagnosis
Disease management
Genetic analysis
Genetic aspects
Genetic research
Hematology
Leukemia
Myeloid leukemia
Patients
Philadelphia chromosome
Philadelphia chromosome (Ph)
Polymerase chain reaction
Protein-tyrosine kinase
Stem cell transplantation
Stem cells
Transplantation
Tyrosine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Although, molecular genetic analyses became more and more important to guide therapy decisions in leukemia, banding cytogenetic analysis has retained its vital role in diagnosis and monitoring of chronic myeloid leukemia (CML), by quick and easy enabling identification of pathognomonic Philadelphia chromosome (Ph). A 45 year old female presented with characteristic hematological features of CML in chronic phase; cytogenetic studies revealed the presence of the typical Ph and a deletion of almost entire long arm of a chromosome 5. 5q deletions have rarely been reported in CML. Those seen yet were either associated with tyrosine kinase inhibitor therapy or detected post allogeneic stem cell transplantation. To our knowledge, this is the first case of Ph positive CML accompanied by a 5q deletion.
ISSN:1755-8166
1755-8166
DOI:10.1186/s13039-021-00539-0