A case of naturally occurring anti-Dia antibody in a young man

The Diego (Di) blood group system comprises 22 antigens located on the band 3 protein, most of which are low-prevalence antigens. The majority of antibodies to Diego system antigens were of clinically insignificant; however anti-Dia, -Dib, -Wra, -ELO and-DISK may cause hemolytic disease of the fetus...

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Published in:Asian journal of transfusion science 2022-07, Vol.16 (2), p.276-279
Main Authors: Iberahim, Salfarina, Noor, Noor, Hassan, Mohd, Bahar, Rosnah, Yusoff, Shafini, Ramli, Marini, Abdul Rahman, Wan, Zulkafli, Zefarina, Abdullah, Marne, Fong, Ho, Mohamed Shihabudin, Tengku, Edinur, Hisham, Che Ghazali, Norul
Format: Article
Language:English
Subjects:
anti-dia
anti-dib
Antibodies
Antigens
Blood groups
Blood transfusions
Case Report
Case reports
diego blood group system
naturally occurring antibody
Viral antibodies
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Summary:The Diego (Di) blood group system comprises 22 antigens located on the band 3 protein, most of which are low-prevalence antigens. The majority of antibodies to Diego system antigens were of clinically insignificant; however anti-Dia, -Dib, -Wra, -ELO and-DISK may cause hemolytic disease of the fetus and newborn (HDFN) and transfusion reaction. We reported a case of naturally occurring of anti-Dia in a young man who presented to our hospital for wound debridement of fingers injury. His serological results were suggestive of anti-Dia antibody, and his molecular blood group showed he has Di (a-b+) antigen. Anti-Dia may be clinically significant. It can cause mild-to-severe HDFN, but there are only infrequent reports of it being clearly implicated in a hemolytic transfusion reaction. We suggest the need for reagent red blood cell panels to include Dia antigen-positive cells in antibody identification tests for our populations.
ISSN:0973-6247
1998-3565
DOI:10.4103/ajts.ajts_136_21