The effect of silver nanoparticles on learning and memory in rodents: "a systematic review"

Silver nanoparticles (AgNPs) are widely used in medicine owing to their antiseptic activity and inducing cell death. Despite AgNPs' importance in nano-engineering and medical benefits, animal studies have shown silver toxicity can damage multiple organs such as the lungs, liver, kidneys, intest...

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Published in:Journal of occupational medicine and toxicology (London, England) England), 2023-08, Vol.18 (1), p.15-15, Article 15
Main Authors: Safaei, Farshad, Farimaneh, Javad, Rajabi Mohammad Abad, Ali, Iranmanesh, Ehsan, Arabpour, Fatemeh, Doostishoar, Farzad, Taherizadeh, Zahra
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animal cognition
Animals
Brain damage
Care and treatment
Cell death
Cognitive ability
Diagnosis
Fear conditioning
Health aspects
Intestine
Kidneys
Learning
Learning disabilities
Medical research
Memory
Memory, Disorders of
Mice
MWM
Nanoengineering
Nanoparticles
NORT
Rats
Review
Rodents
Search engines
Silver
Silver Nanoparticles
Systematic review
Toxicity
Tumor necrosis factor-TNF
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Summary:Silver nanoparticles (AgNPs) are widely used in medicine owing to their antiseptic activity and inducing cell death. Despite AgNPs' importance in nano-engineering and medical benefits, animal studies have shown silver toxicity can damage multiple organs such as the lungs, liver, kidneys, intestines, and brain. Several investigations revealed the correlation between Ag administration by different methods with impaired cognitive and behavioral abilities. Therefore, this systematic review aimed to conclude on the existing evidence of impairments in learning and memory that were changed in rodents exposed to AgNPs. Main searches were retrieved in Google Scholar, Scopus, Web of Science, and PubMed databases from 1979 to 2022. Eligibility Criteria were applied to select and extract 15 articles among 892. Learning and memory abilities of rats and mice in screened studies were evaluated with MWM, NORT, PAL, T-maze, Y-maze, contextual fear conditioning, Radial Arm Maze and Carousel Maze test. Data have shown various sizes from 10 to 100 nm could affect the results of tests among animals exposed to AgNPs compared with control animals. However, in some treatments, results achieved from tests have not demonstrated significant differences between control and treated groups. Studies have revealed that treatment with Ag-NPs of different sizes can impair learning and memory skills in rats and mice.
ISSN:1745-6673
1745-6673
DOI:10.1186/s12995-023-00381-7