Regulation of neuroinflammatory properties of glial cells by T cell effector molecules

Multiple sclerosis （MS） is a chronic inflammatory and neurodegenerative disorder that is thought to be mediated by autoreactive T lymphocytes that find their way into the central nervous system （CNS）. The pathological mechanism of MS is still being elucidated but it involves complex interactions bet...

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Bibliographic Details
Published in:Neural regeneration research 2018-02, Vol.13 (2), p.234-236
Main Authors: Prajeeth, Chittappen, Huehn, Jochen, Stangel, Martin
Format: Article
Language:English
Subjects:
Antigens
Biological response modifiers
Chemokines
Cytokines
Development and progression
Genotype & phenotype
Glia
Growth factors
Health aspects
Immunopathology
Ligands
Lymphocytes
Multiple sclerosis
Neurological research
Neuropathology
Neurotoxicity
Pathogens
Pathology
Physiological aspects
Recruitment
T cells
Tumor necrosis factor-TNF
房间
分子
性质
神经系统
淋巴细胞
相互作用
病理学
CNS
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Description
Summary:Multiple sclerosis （MS） is a chronic inflammatory and neurodegenerative disorder that is thought to be mediated by autoreactive T lymphocytes that find their way into the central nervous system （CNS）. The pathological mechanism of MS is still being elucidated but it involves complex interactions between infiltrating immune cells and resi- dent glial cells within the CNS that culminate into strong neuroinflammation and axonal damage.
ISSN:1673-5374
1876-7958
DOI:10.4103/1673-5374.226385