Maternal chitosan oligosaccharide supplementation during late gestation and lactation optimizes placental function in sows and intestinal function in 21-day-old IUGR suckling piglets

Maternal dietary supplementation with chitosan oligosaccharide (COS) has been considered as a potential intervention to mitigate the occurrence of intrauterine growth restriction (IUGR) and improve postnatal growth. The present study investigated the effect of COS as a dietary supplement for sows du...

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Bibliographic Details
Published in:Frontiers in veterinary science 2024-11, Vol.11, p.1463707
Main Authors: Wang, Xintao, Fang, Tingting, Chen, Daiwen, Pu, Junning, Tian, Gang, He, Jun, Zheng, Ping, Mao, Xiangbing, Wu, Aimin, Yu, Bing
Format: Article
Language:English
Subjects:
chitosan oligosaccharide
intestine
intrauterine growth retardation
piglets
placenta
sows
Veterinary Science
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Summary:Maternal dietary supplementation with chitosan oligosaccharide (COS) has been considered as a potential intervention to mitigate the occurrence of intrauterine growth restriction (IUGR) and improve postnatal growth. The present study investigated the effect of COS as a dietary supplement for sows during late gestation and lactation on their productivity, placental function, and the intestinal health of IUGR piglets. From day (d) 85 of late gestation to d 21 of lactation, 30 sows were randomly divided into either a control group (basal diet) or a COS group (basal diet + 100 mg kg COS). At d 21 of lactation, eight normal and eight IUGR littermates from eight litters belong to control sows, as well as eight IUGR littermates from COS sows, were selected for further analysis. The results showed a significant reduction in the number of stillbirths and mummies in COS groups (  
ISSN:2297-1769
2297-1769
DOI:10.3389/fvets.2024.1463707