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Maternal chitosan oligosaccharide supplementation during late gestation and lactation optimizes placental function in sows and intestinal function in 21-day-old IUGR suckling piglets
Maternal dietary supplementation with chitosan oligosaccharide (COS) has been considered as a potential intervention to mitigate the occurrence of intrauterine growth restriction (IUGR) and improve postnatal growth. The present study investigated the effect of COS as a dietary supplement for sows du...
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| Published in: | Frontiers in veterinary science 2024-11, Vol.11, p.1463707 |
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| container_title | Frontiers in veterinary science |
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| creator | Wang, Xintao Fang, Tingting Chen, Daiwen Pu, Junning Tian, Gang He, Jun Zheng, Ping Mao, Xiangbing Wu, Aimin Yu, Bing |
| description | Maternal dietary supplementation with chitosan oligosaccharide (COS) has been considered as a potential intervention to mitigate the occurrence of intrauterine growth restriction (IUGR) and improve postnatal growth. The present study investigated the effect of COS as a dietary supplement for sows during late gestation and lactation on their productivity, placental function, and the intestinal health of IUGR piglets. From day (d) 85 of late gestation to d 21 of lactation, 30 sows were randomly divided into either a control group (basal diet) or a COS group (basal diet + 100 mg kg
COS). At d 21 of lactation, eight normal and eight IUGR littermates from eight litters belong to control sows, as well as eight IUGR littermates from COS sows, were selected for further analysis. The results showed a significant reduction in the number of stillbirths and mummies in COS groups (
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| doi_str_mv | 10.3389/fvets.2024.1463707 |
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| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_1a6543dbf46c4d5bb4ce58df95d9abb0</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_1a6543dbf46c4d5bb4ce58df95d9abb0</doaj_id><sourcerecordid>3133737339</sourcerecordid><originalsourceid>FETCH-LOGICAL-c306t-bab36a208a04013cd581e4df7f2d639a17440f800969c18bf9c3c30d64e3c2ac3</originalsourceid><addsrcrecordid>eNpdUsFu1DAQjRCIVqU_wAH5yCWLHTtOfEKogrJSq0qInq2J7WRdvHawk6LyYXwfzm6oWuSDx2_mvRmPXlG8JXhDaSs-9PdmSpsKV2xDGKcNbl4Up1UlmpI0XLx8Ep8U5yndYYxJzRra4tfFCRUcc87xafHnGiYTPTikdnYKCTwKzg45UGoH0WqD0jyOzuyNn2CywSM9R-sH5DIRDSatKHidIbW-wjjZvf1tEhozuFAd6mevDknrUQq_0oFi_ZQlrP8vX5FSw0MZnEbb28tveQb1wy1dRzu4_PE3xaseXDLn631W3H75_P3ia3l1c7m9-HRVKor5VHbQUQ4VbgEzTKjSdUsM033TV5pTAaRhDPctxoILRdquF4pmpubMUFWBomfF9qirA9zJMdo9xAcZwMoDEOIgIU5WOSMJ8JpR3fWMK6brrmPK1K3uRa0FdB3OWh-PWuPc7Y1ethLBPRN9nvF2J4dwLwnhecKGZoX3q0IMP-e8N7m3SRnnwJswJ0kJpU0-VOTS6liqYkgpmv6xD8FyMZA8GEguBpKrgTLp3dMJHyn_7EL_AognySA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3133737339</pqid></control><display><type>article</type><title>Maternal chitosan oligosaccharide supplementation during late gestation and lactation optimizes placental function in sows and intestinal function in 21-day-old IUGR suckling piglets</title><source>PubMed Central</source><creator>Wang, Xintao ; Fang, Tingting ; Chen, Daiwen ; Pu, Junning ; Tian, Gang ; He, Jun ; Zheng, Ping ; Mao, Xiangbing ; Wu, Aimin ; Yu, Bing</creator><creatorcontrib>Wang, Xintao ; Fang, Tingting ; Chen, Daiwen ; Pu, Junning ; Tian, Gang ; He, Jun ; Zheng, Ping ; Mao, Xiangbing ; Wu, Aimin ; Yu, Bing</creatorcontrib><description>Maternal dietary supplementation with chitosan oligosaccharide (COS) has been considered as a potential intervention to mitigate the occurrence of intrauterine growth restriction (IUGR) and improve postnatal growth. The present study investigated the effect of COS as a dietary supplement for sows during late gestation and lactation on their productivity, placental function, and the intestinal health of IUGR piglets. From day (d) 85 of late gestation to d 21 of lactation, 30 sows were randomly divided into either a control group (basal diet) or a COS group (basal diet + 100 mg kg
COS). At d 21 of lactation, eight normal and eight IUGR littermates from eight litters belong to control sows, as well as eight IUGR littermates from COS sows, were selected for further analysis. The results showed a significant reduction in the number of stillbirths and mummies in COS groups (
< 0.05). Maternal dietary supplementation with COS also significantly up-regulated the expression levels of
,
, and
mRNA in the placenta of IUGR piglets compared to those in control group (
< 0.05). Furthermore, there was a significant decrease in MDA content and a significant increase in GSH content in the placenta of IUGR piglets from COS sows compared to those from control group (
< 0.05). Additionally, the expression levels of
and
mRNA as well as claudin1 protein significantly up-regulated in the jejunum of 21-day-old IUGR piglets from COS sows group compared to those from control group (
< 0.05). Moreover,
mRNA expression level was significantly increased while MDA content was significantly reduced in the jejunum of 21-day-old IUGR piglets from COS sows group compared to those from control group (
< 0.05). The results indicated that maternal dietary COS supplementation during late gestation effectively reduced the incidence of stillbirths and mummies, potentially linked to enhanced placental function, reduced oxidative stress, and improved immune status. Furthermore, maternal dietary COS supplementation exhibited positive impact on intestinal digestive and absorptive function, intestinal barrier integrity, intestinal antioxidant capacity and immune status in 21-day-old suckling IUGR piglets.</description><identifier>ISSN: 2297-1769</identifier><identifier>EISSN: 2297-1769</identifier><identifier>DOI: 10.3389/fvets.2024.1463707</identifier><identifier>PMID: 39606660</identifier><language>eng</language><publisher>Switzerland: Frontiers Media S.A</publisher><subject>chitosan oligosaccharide ; intestine ; intrauterine growth retardation ; piglets ; placenta ; sows ; Veterinary Science</subject><ispartof>Frontiers in veterinary science, 2024-11, Vol.11, p.1463707</ispartof><rights>Copyright © 2024 Wang, Fang, Chen, Pu, Tian, He, Zheng, Mao, Wu and Yu.</rights><rights>Copyright © 2024 Wang, Fang, Chen, Pu, Tian, He, Zheng, Mao, Wu and Yu. 2024 Wang, Fang, Chen, Pu, Tian, He, Zheng, Mao, Wu and Yu</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c306t-bab36a208a04013cd581e4df7f2d639a17440f800969c18bf9c3c30d64e3c2ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600973/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600973/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39606660$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xintao</creatorcontrib><creatorcontrib>Fang, Tingting</creatorcontrib><creatorcontrib>Chen, Daiwen</creatorcontrib><creatorcontrib>Pu, Junning</creatorcontrib><creatorcontrib>Tian, Gang</creatorcontrib><creatorcontrib>He, Jun</creatorcontrib><creatorcontrib>Zheng, Ping</creatorcontrib><creatorcontrib>Mao, Xiangbing</creatorcontrib><creatorcontrib>Wu, Aimin</creatorcontrib><creatorcontrib>Yu, Bing</creatorcontrib><title>Maternal chitosan oligosaccharide supplementation during late gestation and lactation optimizes placental function in sows and intestinal function in 21-day-old IUGR suckling piglets</title><title>Frontiers in veterinary science</title><addtitle>Front Vet Sci</addtitle><description>Maternal dietary supplementation with chitosan oligosaccharide (COS) has been considered as a potential intervention to mitigate the occurrence of intrauterine growth restriction (IUGR) and improve postnatal growth. The present study investigated the effect of COS as a dietary supplement for sows during late gestation and lactation on their productivity, placental function, and the intestinal health of IUGR piglets. From day (d) 85 of late gestation to d 21 of lactation, 30 sows were randomly divided into either a control group (basal diet) or a COS group (basal diet + 100 mg kg
COS). At d 21 of lactation, eight normal and eight IUGR littermates from eight litters belong to control sows, as well as eight IUGR littermates from COS sows, were selected for further analysis. The results showed a significant reduction in the number of stillbirths and mummies in COS groups (
< 0.05). Maternal dietary supplementation with COS also significantly up-regulated the expression levels of
,
, and
mRNA in the placenta of IUGR piglets compared to those in control group (
< 0.05). Furthermore, there was a significant decrease in MDA content and a significant increase in GSH content in the placenta of IUGR piglets from COS sows compared to those from control group (
< 0.05). Additionally, the expression levels of
and
mRNA as well as claudin1 protein significantly up-regulated in the jejunum of 21-day-old IUGR piglets from COS sows group compared to those from control group (
< 0.05). Moreover,
mRNA expression level was significantly increased while MDA content was significantly reduced in the jejunum of 21-day-old IUGR piglets from COS sows group compared to those from control group (
< 0.05). The results indicated that maternal dietary COS supplementation during late gestation effectively reduced the incidence of stillbirths and mummies, potentially linked to enhanced placental function, reduced oxidative stress, and improved immune status. Furthermore, maternal dietary COS supplementation exhibited positive impact on intestinal digestive and absorptive function, intestinal barrier integrity, intestinal antioxidant capacity and immune status in 21-day-old suckling IUGR piglets.</description><subject>chitosan oligosaccharide</subject><subject>intestine</subject><subject>intrauterine growth retardation</subject><subject>piglets</subject><subject>placenta</subject><subject>sows</subject><subject>Veterinary Science</subject><issn>2297-1769</issn><issn>2297-1769</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpdUsFu1DAQjRCIVqU_wAH5yCWLHTtOfEKogrJSq0qInq2J7WRdvHawk6LyYXwfzm6oWuSDx2_mvRmPXlG8JXhDaSs-9PdmSpsKV2xDGKcNbl4Up1UlmpI0XLx8Ep8U5yndYYxJzRra4tfFCRUcc87xafHnGiYTPTikdnYKCTwKzg45UGoH0WqD0jyOzuyNn2CywSM9R-sH5DIRDSatKHidIbW-wjjZvf1tEhozuFAd6mevDknrUQq_0oFi_ZQlrP8vX5FSw0MZnEbb28tveQb1wy1dRzu4_PE3xaseXDLn631W3H75_P3ia3l1c7m9-HRVKor5VHbQUQ4VbgEzTKjSdUsM033TV5pTAaRhDPctxoILRdquF4pmpubMUFWBomfF9qirA9zJMdo9xAcZwMoDEOIgIU5WOSMJ8JpR3fWMK6brrmPK1K3uRa0FdB3OWh-PWuPc7Y1ethLBPRN9nvF2J4dwLwnhecKGZoX3q0IMP-e8N7m3SRnnwJswJ0kJpU0-VOTS6liqYkgpmv6xD8FyMZA8GEguBpKrgTLp3dMJHyn_7EL_AognySA</recordid><startdate>20241113</startdate><enddate>20241113</enddate><creator>Wang, Xintao</creator><creator>Fang, Tingting</creator><creator>Chen, Daiwen</creator><creator>Pu, Junning</creator><creator>Tian, Gang</creator><creator>He, Jun</creator><creator>Zheng, Ping</creator><creator>Mao, Xiangbing</creator><creator>Wu, Aimin</creator><creator>Yu, Bing</creator><general>Frontiers Media S.A</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20241113</creationdate><title>Maternal chitosan oligosaccharide supplementation during late gestation and lactation optimizes placental function in sows and intestinal function in 21-day-old IUGR suckling piglets</title><author>Wang, Xintao ; Fang, Tingting ; Chen, Daiwen ; Pu, Junning ; Tian, Gang ; He, Jun ; Zheng, Ping ; Mao, Xiangbing ; Wu, Aimin ; Yu, Bing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c306t-bab36a208a04013cd581e4df7f2d639a17440f800969c18bf9c3c30d64e3c2ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>chitosan oligosaccharide</topic><topic>intestine</topic><topic>intrauterine growth retardation</topic><topic>piglets</topic><topic>placenta</topic><topic>sows</topic><topic>Veterinary Science</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xintao</creatorcontrib><creatorcontrib>Fang, Tingting</creatorcontrib><creatorcontrib>Chen, Daiwen</creatorcontrib><creatorcontrib>Pu, Junning</creatorcontrib><creatorcontrib>Tian, Gang</creatorcontrib><creatorcontrib>He, Jun</creatorcontrib><creatorcontrib>Zheng, Ping</creatorcontrib><creatorcontrib>Mao, Xiangbing</creatorcontrib><creatorcontrib>Wu, Aimin</creatorcontrib><creatorcontrib>Yu, Bing</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in veterinary science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xintao</au><au>Fang, Tingting</au><au>Chen, Daiwen</au><au>Pu, Junning</au><au>Tian, Gang</au><au>He, Jun</au><au>Zheng, Ping</au><au>Mao, Xiangbing</au><au>Wu, Aimin</au><au>Yu, Bing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal chitosan oligosaccharide supplementation during late gestation and lactation optimizes placental function in sows and intestinal function in 21-day-old IUGR suckling piglets</atitle><jtitle>Frontiers in veterinary science</jtitle><addtitle>Front Vet Sci</addtitle><date>2024-11-13</date><risdate>2024</risdate><volume>11</volume><spage>1463707</spage><pages>1463707-</pages><issn>2297-1769</issn><eissn>2297-1769</eissn><abstract>Maternal dietary supplementation with chitosan oligosaccharide (COS) has been considered as a potential intervention to mitigate the occurrence of intrauterine growth restriction (IUGR) and improve postnatal growth. The present study investigated the effect of COS as a dietary supplement for sows during late gestation and lactation on their productivity, placental function, and the intestinal health of IUGR piglets. From day (d) 85 of late gestation to d 21 of lactation, 30 sows were randomly divided into either a control group (basal diet) or a COS group (basal diet + 100 mg kg
COS). At d 21 of lactation, eight normal and eight IUGR littermates from eight litters belong to control sows, as well as eight IUGR littermates from COS sows, were selected for further analysis. The results showed a significant reduction in the number of stillbirths and mummies in COS groups (
< 0.05). Maternal dietary supplementation with COS also significantly up-regulated the expression levels of
,
, and
mRNA in the placenta of IUGR piglets compared to those in control group (
< 0.05). Furthermore, there was a significant decrease in MDA content and a significant increase in GSH content in the placenta of IUGR piglets from COS sows compared to those from control group (
< 0.05). Additionally, the expression levels of
and
mRNA as well as claudin1 protein significantly up-regulated in the jejunum of 21-day-old IUGR piglets from COS sows group compared to those from control group (
< 0.05). Moreover,
mRNA expression level was significantly increased while MDA content was significantly reduced in the jejunum of 21-day-old IUGR piglets from COS sows group compared to those from control group (
< 0.05). The results indicated that maternal dietary COS supplementation during late gestation effectively reduced the incidence of stillbirths and mummies, potentially linked to enhanced placental function, reduced oxidative stress, and improved immune status. Furthermore, maternal dietary COS supplementation exhibited positive impact on intestinal digestive and absorptive function, intestinal barrier integrity, intestinal antioxidant capacity and immune status in 21-day-old suckling IUGR piglets.</abstract><cop>Switzerland</cop><pub>Frontiers Media S.A</pub><pmid>39606660</pmid><doi>10.3389/fvets.2024.1463707</doi><oa>free_for_read</oa></addata></record> |
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| subjects | chitosan oligosaccharide intestine intrauterine growth retardation piglets placenta sows Veterinary Science |
| title | Maternal chitosan oligosaccharide supplementation during late gestation and lactation optimizes placental function in sows and intestinal function in 21-day-old IUGR suckling piglets |
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