Unraveling the link between sterol ester and colorectal cancer: a two-sample mendelian randomization study

Several studies reported the sterol ester (SE), a subclass of subtype of cholesterol ester (CE), is associated with the incidence of colorectal cancer (CRC). Nevertheless, the causal relationship of SE on CRC remains unknown. A two-sample Mendelian randomization study was performed with the summary...

Full description

Saved in:
Bibliographic Details
Published in:BMC cancer 2024-11, Vol.24 (1), p.1462-6, Article 1462
Main Authors: Liu, Chuanyuan, Xie, Junfeng, Ye, Baolong, Zhong, Junqiao, Xu, Xin
Format: Article
Language:English
Subjects:
Analysis
Analysis and chemistry
Blood
Cancer
Care and treatment
Causal
Cholesterol
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - genetics
Development and progression
Diagnosis
Enzymes
Esters
Genetic
Genetic aspects
Genetic Predisposition to Disease
Genome-wide association studies
Genome-Wide Association Study
Genomes
Genomic analysis
Genomics
Health aspects
Humans
Incidence
Lipid metabolism
Lipids
Margarine
Mendelian randomization
Mendelian Randomization Analysis
Metabolism
Methods
Oncology, Experimental
Pleiotropy
Polymorphism, Single Nucleotide
Relapse
Sensitivity analysis
Single-nucleotide polymorphism
Statistical analysis
Sterol ester
Sterols
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Several studies reported the sterol ester (SE), a subclass of subtype of cholesterol ester (CE), is associated with the incidence of colorectal cancer (CRC). Nevertheless, the causal relationship of SE on CRC remains unknown. A two-sample Mendelian randomization study was performed with the summary statistics of SE (27:1/14:0) which is from the largest available genome-wide association study meta-analysis(n = 377277) conducted by FinnGen consortium. The summary data were obtained from UK Biobank repository (377673 cases and 372016 controls). And we used a relative relaxed filter (p 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-024-13228-z