Interaction between Akkermansia muciniphila and Diet Is Associated with Proinflammatory Index in School-Aged Children

Background: Imbalance in the intestinal microbiota can lead to chronic low-grade inflammation. Diet may influence this association. In this study, we aimed to evaluate the interaction between Akkermansia muciniphila (A. muciniphila) and dietary patterns using a proinflammatory index. Methods: We con...

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Published in:Children (Basel) 2023-11, Vol.10 (11), p.1799
Main Authors: Ayala-García, Juan Carlos, García-Vera, Alba Mariel, Lagunas-Martínez, Alfredo, Orbe-Orihuela, Yaneth Citlalli, Castañeda-Márquez, Ana Cristina, Díaz-Benítez, Cinthya Estefhany, Bermúdez-Morales, Víctor Hugo, Cruz, Miguel, Bahena-Román, Margarita, Burguete-García, Ana Isabel
Format: Article
Language:English
Subjects:
Carbohydrates
Cytokines
Diet
dietary patterns
Exercise
Food
Genetic testing
gut microbiota
Inflammation
Metabolism
Microbiota
Permeability
Questionnaires
Tumor necrosis factor-TNF
Variables
Citations: Items that this one cites
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Summary:Background: Imbalance in the intestinal microbiota can lead to chronic low-grade inflammation. Diet may influence this association. In this study, we aimed to evaluate the interaction between Akkermansia muciniphila (A. muciniphila) and dietary patterns using a proinflammatory index. Methods: We conducted a cross-sectional study with school-aged children. We quantified the relative abundance (RA) of A. muciniphila in feces using a polymerase chain reaction. We collected dietary information through employing a food frequency questionnaire and generated dietary patterns using principal component analysis. We generated a proinflammatory index from serum levels of interleukin-6, interleukin-10, tumor necrosis factor alpha, and adiponectin validated by receptor operating characteristic curves. We evaluated the association between A. muciniphila and the proinflammatory index using logistic regression, including an interaction term with dietary patterns. Results: We found that children with a low RA of A. muciniphila and a high intake of simple carbohydrates and saturated fats had increased odds of being high on the proinflammatory index. However, when the consumption of this dietary pattern is low, children with a low RA of A. muciniphila had decreased odds of being high on the proinflammatory index. Conclusions: Our results suggest that the simultaneous presence of A. muciniphila and diet have a more significant impact on the presence of being high on the proinflammatory index compared to both factors separately.
ISSN:2227-9067
2227-9067
DOI:10.3390/children10111799