Qatari Genotype May Contribute to Complications in Type 2 Diabetes

Objective. There is increasing evidence of a strong genetic component in type 2 diabetes (T2DM) that may contribute to diabetes complications. Given the high prevalence of diabetes with its associated complications in the Middle East, we sought to determine if the genotype within a Middle East popul...

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Bibliographic Details
Published in:Journal of diabetes research 2020, Vol.2020 (2020), p.1-6
Main Authors: Butler, Alexandra E., Rodriguez-Flores, Juan, Robay, Amal, Dargham, Soha R., Atkin, Stephen L., Dakroury, Youssra, Crystal, Ronald G.
Format: Article
Language:English
Subjects:
Adult
Age
Arabs - genetics
Asians - genetics
Blacks - genetics
Blood pressure
Body mass index
Diabetes
Diabetes Complications - etiology
Diabetes Complications - genetics
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - genetics
Diabetic Neuropathies - etiology
Diabetic Neuropathies - genetics
Diabetic neuropathy
Diabetic retinopathy
Diabetic Retinopathy - etiology
Diabetic Retinopathy - genetics
Disease
Fasting
Female
Females
Genetic Predisposition to Disease
Genotype
Genotype & phenotype
Glucose
Humans
Hypertension - etiology
Hypertension - genetics
Male
Middle Aged
Polymorphism, Single Nucleotide
Population
Qatar
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Summary:Objective. There is increasing evidence of a strong genetic component in type 2 diabetes (T2DM) that may contribute to diabetes complications. Given the high prevalence of diabetes with its associated complications in the Middle East, we sought to determine if the genotype within a Middle East population may be contributory. Therefore, three genotype-based Qatari ancestral groups, Q1 Arab Bedouin, Q2 Asian/Persian, and Q3 sub-Saharan African, with a fourth admixed group were correlated with T2DM prevalence and its complications to determine if they differed between the 4 Qatari ancestries, particularly for the SLMAP allele-associated diabetic retinopathy. Methods. In this cross-sectional study, 398 Qatari subjects, 220 with and 178 without T2DM, were genotyped by Affymetrix 500k SNP arrays. Ancestry was correlated with diabetes complications. Results. 398 subjects were included, the mean age was 49.8 years, and 56.8% were male. The genotype-based ancestry and T2DM prevalence were as follows: 164 (41.2%) with ancestry Q1, 60.4% with T2DM; 149 (37.4%) with ancestry Q2, 49.7% with T2DM; 31 (7.8%) with ancestry Q3, 61.3% with T2DM; and 54 (13.6%) with “admixed” ancestry, 51.9% with T2DM. For patients with diabetes, hypertension (p
ISSN:2314-6745
2314-6753
DOI:10.1155/2020/6356973