Set3 Is Required for Asexual Development, Aflatoxin Biosynthesis, and Fungal Virulence in Aspergillus flavus

is an opportunistic pathogenic fungus for both plant and animal that produces carcinogenic toxins termed aflatoxins (AFs). To identify possible genetic targets to reduce AF contamination, in this study, we have characterized a novel Set3, and it shares sequence homology with the yeast protein Set3....

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Bibliographic Details
Published in:Frontiers in microbiology 2019-03, Vol.10, p.530-530
Main Authors: Lan, Huahui, Wu, Lianghuan, Fan, Kun, Sun, Ruilin, Yang, Guang, Zhang, Feng, Yang, Kunlong, Lin, Xiaolu, Chen, Yanhong, Tian, Jun, Wang, Shihua
Format: Article
Language:English
Subjects:
aflatoxin biosynthesis
Aspergillus flavus
Microbiology
regulate
reproduction
Set3
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Summary:is an opportunistic pathogenic fungus for both plant and animal that produces carcinogenic toxins termed aflatoxins (AFs). To identify possible genetic targets to reduce AF contamination, in this study, we have characterized a novel Set3, and it shares sequence homology with the yeast protein Set3. The deletion mutants present no difference in growth rate but alterations in asexual development and secondary metabolite production when compared to the wild type. Specifically, deletion of gene decreases conidiophore formation and conidial production through downregulating expression of and genes. In addition, normal levels of are required for sclerotial development and expression of sclerotia-related genes and . Further analyses demonstrated that Set3 negatively regulates AF production as well as the concomitant expression of genes in the AF gene cluster. Importantly, our results also display that Set3 is involved in crop kernel colonization. Taking together, these results reveal that a novel Set3 plays crucial roles in morphological development, secondary metabolism, and fungal virulence in .
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2019.00530