Exercise response to oxygen supplementation is not associated with survival in hypoxemic patients with obstructive lung disease

• Published in: International journal of chronic obstructive pulmonary disease 2018-01, Vol.13, p.1607-1612
• Main Authors: Sadaka, Ahmed S, Montgomery, Andrew J, Mourad, Sahar M, Polkey, Michael I, Hopkinson, Nicholas S
• Format: Article
• Language: English
• Subjects: 6-min walk test; Analysis; Anoxemia; Body mass index; Carbon monoxide; Chronic obstructive pulmonary disease; Comorbidity; Dyspnea; Exercise; Glycosylated hemoglobin; Heart rate; Hemoglobin; Hemoglobins; hypoxemia; Lung diseases; Medical prognosis; Medical research; Mortality; obstructive lung disease; Original Research; oxygen; Oxygen saturation; Oxygen therapy; Patient outcomes; Patients; Physical fitness; Physiology; Pulse oximetry; Regression analysis; Respiratory tract diseases; Variables
• ISSN: 1178-2005; 1176-9106; 1178-2005
• DOI: 10.2147/COPD.S163119

Hypoxemia is associated with more severe lung disease and worse outcomes. In some patients with chronic obstructive lung diseases who desaturate on exertion, supplemental oxygen improves exercise capacity. The clinical significance of this exercise response to oxygen supplementation is not known. We identified chronic obstructive lung disease patients at our center who underwent a 6-minute walking test (6MWT) for ambulatory oxygen assessment and who desaturated breathing air and therefore had an additional walk test on supplemental oxygen, between August 2006 and June 2016. Responders were defined as walking ≥26 m further with oxygen. Survival was determined up to February 1, 2017. We compared survival in oxygen responders and nonresponders in patients with obstructive lung diseases. One hundred and seventy-four patients were included in the study, median age 70 years. Seventy-seven (44.3%) of the patients were oxygen responders. Borg dyspnea score improved by 1.4 (±1.4) units (