CPEB2 inhibit cell proliferation through upregulating p21 mRNA stability in glioma

Glioma is the most common primary malignant brain tumor in adults and remains an incurable disease at present. Thus, there is an urgent need for progress in finding novel molecular mechanisms that control the progression of glioma which could be used as therapeutic targets for glioma patients. The R...

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Bibliographic Details
Published in:Scientific reports 2023-12, Vol.13 (1), p.23103-23103, Article 23103
Main Authors: Zhao, Guang, Zhao, Zhongjun, Xia, Mingyi, Xiao, Lishun, Zhu, Bao, Wang, Hui, Li, Xiang, Di, Jiehui
Format: Article
Language:English
Subjects:
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Apoptosis
Brain cancer
Brain tumors
Cell cycle
Cell growth
Cell proliferation
Cyclin-dependent kinase inhibitor p21
Down-regulation
Glioma
Glioma cells
Humanities and Social Sciences
Molecular modelling
mRNA stability
multidisciplinary
Pathogenesis
Polyadenylation
RNA-binding protein
Science
Science (multidisciplinary)
Therapeutic targets
Tumor suppressor genes
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Summary:Glioma is the most common primary malignant brain tumor in adults and remains an incurable disease at present. Thus, there is an urgent need for progress in finding novel molecular mechanisms that control the progression of glioma which could be used as therapeutic targets for glioma patients. The RNA binding protein cytoplasmic polyadenylate element-binding protein 2 (CPEB2) is involved in the pathogenesis of several tumors. However, the role of CPEB2 in glioma progression is unknown. In this study, the functional characterization of the role and molecular mechanism of CPEB2 in glioma were examined using a series of biological and cellular approaches in vitro and in vivo. Our work shows CPEB2 is significantly downregulated in various glioma patient cohorts. Functional characterization of CPEB2 by overexpression and knockdown revealed that it inhibits glioma cell proliferation and promotes apoptosis. CPEB2 exerts an anti-tumor effect by increasing p21 mRNA stability and inducing G1 cell cycle arrest in glioma. Overall, this work stands as the first report of CPEB2 downregulation and involvement in glioma pathogenesis, and identifies CPEB2 as an important tumor suppressor gene through targeting p21 in glioma, which revealed that CPEB2 may become a promising predictive biomarker for prognosis in glioma patients.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-50848-0