An insight in to Paget′s disease of bone

Paget′s disease of bone (PDB) is a common disorder which may affect one or many bones. Although many patients are asymptomatic, a variety of symptoms and complications may occur. PDB is a focal disorder of bone turnover characterized by excessive bone resorption coupled with bone formation. PDB begi...

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Bibliographic Details
Published in:Nigerian journal of surgery 2014, Vol.20 (1), p.9-15
Main Authors: Sabharwal, Robin, Gupta, Shivangi, Sepolia, Shipra, Panigrahi, Rajat, Mohanty, Saumyakanta, Subudhi, SantoshKumar, Kumar, Manish
Format: Article
Language:English
Subjects:
Osteoclast
osteoprotegerin
receptor activator of NF-κB
receptor activator of NF-κB ligand
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Summary:Paget′s disease of bone (PDB) is a common disorder which may affect one or many bones. Although many patients are asymptomatic, a variety of symptoms and complications may occur. PDB is a focal disorder of bone turnover characterized by excessive bone resorption coupled with bone formation. PDB begins with a period of increased osteoclastic activity and bone resorption, followed by increased osteoblast production of woven bone that is poorly mineralized. In the final phase of the disease process, dense cortical and trabecular bone deposition predominates, but the bone is sclerotic and poorly organized and lacks the structural integrity and strength of normal bone. This article briefly reviews the etiopathogenesis, clinical radiographic and histological features of Paget′s disease.
ISSN:1117-6806
2278-7100
DOI:10.4103/1117-6806.127098