Synthesis of 2-azetidinone derivatives of 6-nitro-1H-indazole and their biological importance

A new series of 3-chloro-1-{[2-(6-nitro-1H-indazol-1-yl)ethyl]amino}-4-(substituted phenyl)-2-azetidinones (4a-j) was synthesized in four steps from 6-nitro-1H-indazole and characterized by IR, ¹H NMR, 13C NMR, FAB-mass spectrometry and chemical methods. Compounds 4(a-j) were screened in vitro for t...

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Bibliographic Details
Published in:Química Nova 2012, Vol.35 (5), p.914-919
Main Authors: Samadhiya, Pushkal, Sharma, Ritu, Srivastava, Santosh K., Srivastava, S. D.
Format: Article
Language:English
Subjects:
azetidinone
biosignificance
CHEMISTRY, MULTIDISCIPLINARY
synthesis
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Summary:A new series of 3-chloro-1-{[2-(6-nitro-1H-indazol-1-yl)ethyl]amino}-4-(substituted phenyl)-2-azetidinones (4a-j) was synthesized in four steps from 6-nitro-1H-indazole and characterized by IR, ¹H NMR, 13C NMR, FAB-mass spectrometry and chemical methods. Compounds 4(a-j) were screened in vitro for their antibacterial, antifungal and antitubercular activities against some selected microorganism and for their antiinflammatory activity (in vivo) against albino rats (either sex). All above activities of compounds 4(a-j) showed acceptable results.
ISSN:0100-4042
1678-7064
DOI:10.1590/S0100-40422012000500010