Fetal Alcohol Spectrum Disorder and Iron Homeostasis

Prenatal alcohol exposure results in a spectrum of behavioral, cognitive, and morphological abnormalities collectively referred to as fetal alcohol spectrum disorder (FASD). FASD presents with significant phenotypic variability and may be modified by gestational variables such as maternal nutritiona...

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Bibliographic Details
Published in:Nutrients 2022-10, Vol.14 (20), p.4223
Main Authors: Bradley, Regan, Lakpa, Koffi L, Burd, Michael, Mehta, Sunil, Katusic, Maja Z, Greenmyer, Jacob R
Format: Article
Language:English
Subjects:
Abnormalities
Anemia
Animal cognition
Binding sites
Blood
Central nervous system
Child development deviations
Complications and side effects
Development and progression
Developmental disabilities
Drinking in pregnancy
Effect of alcohol on
fetal alcohol spectrum disorders
Fetal alcohol syndrome
Fetus
Fetuses
Genetic variability
Health aspects
Homeostasis
Iron
iron deficiency
Iron deficiency diseases
Iron in the body
iron supplementation
maternal/fetal anemia
maternal/fetal nutrition
Metabolism
Neurodevelopmental disorders
Nutrient deficiency
Nutrients
Nutrition
Nutritional status
Oxidation
Physiological aspects
Placenta
Plasma
Pregnancy
Pregnant women
Prenatal experience
Prenatal influences
Prevention
Proteins
Review
Risk factors
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Description
Summary:Prenatal alcohol exposure results in a spectrum of behavioral, cognitive, and morphological abnormalities collectively referred to as fetal alcohol spectrum disorder (FASD). FASD presents with significant phenotypic variability and may be modified by gestational variables such as maternal nutritional status. Iron serves a critical function in the development of and processes within central nervous system (CNS) structures. Gestational iron deficiency alters CNS development and may contribute to neurodevelopmental impairment in FASD. This review explores the relationship between iron deficiency and fetal alcohol spectrum disorder as described in small animal and human studies. Consideration is given to the pathophysiologic mechanisms linking iron homeostasis and prenatal alcohol exposure. Existing data suggest that iron deficiency contributes to the severity of FASD and provide a mechanistic explanation linking these two conditions.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14204223