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Exhaled nitric oxide - circadian variations in healthy subjects

Exhaled nitric oxide (eNO) has been suggested as a marker of airway inflammatory diseases. The level of eNO is influenced by many various factor including age, sex, menstrual cycle, exercise, food, drugs, etc. The aim of our study was to investigate a potential influence of circadian variation on eN...

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Published in:European journal of medical research 2009-12, Vol.14 Suppl 4 (S4), p.6-8, Article 6
Main Authors: Antosova, M, Bencova, A, Psenkova, A, Herle, D, Rozborilova, E
Format: Article
Language:English
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Summary:Exhaled nitric oxide (eNO) has been suggested as a marker of airway inflammatory diseases. The level of eNO is influenced by many various factor including age, sex, menstrual cycle, exercise, food, drugs, etc. The aim of our study was to investigate a potential influence of circadian variation on eNO level in healthy subjects. Measurements were performed in 44 women and 10 men, non-smokers, without respiratory tract infection in last 2 weeks. The eNO was detected at 4-hour intervals from 6 a.m. to 10 p.m. using an NIOX analyzer. We followed the ATS/ERS guidelines for eNO measurement and analysis. Peak of eNO levels were observed at 10 a.m. (11.1 +/- 7.2 ppb), the lowest value was detected at 10 p.m. (10.0 +/- 5.8 ppb). The difference was statistically significant (paired t-test, P
ISSN:0949-2321
2047-783X
2047-783X
DOI:10.1186/2047-783X-14-S4-6