A Double-Site Chemodosimeter for Selective Fluorescence Detection of a Nerve Agent Mimic

A novel two-site chemodosimeter ( ) based on fluorescein skeleton to detect diethyl chlorophosphate (DCP) was designed and synthesized. It is a turn-on fluorescent probe for DCP with good selectivity and obvious color change in aqueous solution. Interestingly, the two oxime groups of as dual respons...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-01, Vol.27 (2), p.489
Main Authors: Guo, Xin, Liu, Chang-Xiang, Lu, Yuan, Wang, Ya-Wen, Peng, Yu
Format: Article
Language:English
Subjects:
Aqueous solutions
chemodosimeter
Color
Computational Chemistry
Cyano groups
diethyl chlorophosphate (DCP)
double-site
Fluorescein
Fluorescein - chemical synthesis
Fluorescein - chemistry
Fluorescence
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Fluorescent indicators
Hydrogen bonds
Nerve agents
Nerve Agents - analysis
Nerve Agents - chemistry
Organophosphorus Compounds - analysis
Organophosphorus Compounds - chemistry
Rings (mathematics)
Selectivity
Sensitivity and Specificity
Spectrometry, Fluorescence - methods
Water - chemistry
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Summary:A novel two-site chemodosimeter ( ) based on fluorescein skeleton to detect diethyl chlorophosphate (DCP) was designed and synthesized. It is a turn-on fluorescent probe for DCP with good selectivity and obvious color change in aqueous solution. Interestingly, the two oxime groups of as dual response sites initiated different reactions with DCP to form a cyano group and an isoxazole ring, respectively. The corresponding mechanism was confirmed by H NMR, MS and DFT calculation. Moreover, could be used as a fluorescent test paper to detect DCP vapor.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27020489