Transcriptional Regulation of Channelopathies in Genetic and Acquired Epilepsies

Epilepsy is a common neurological disorder characterized by recurrent uncontrolled seizures and has an idiopathic " " etiology or a symptomatic " " component. Genetic studies have revealed that many epilepsy susceptibility genes encode ion channels, including voltage-gated sodium...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in cellular neuroscience 2020-01, Vol.13, p.587-587
Main Authors: van Loo, Karen M J, Becker, Albert J
Format: Article
Language:English
Subjects:
Binding sites
Calcium channels
Calcium channels (voltage-gated)
Cellular Neuroscience
channelopathies
Convulsions & seizures
Disease
Epilepsy
Etiology
Gene regulation
Genes
genetic and acquired epilepsies
Genomes
Haplotypes
ion channels
Ligands
Mutation
Neural coding
Neurodevelopmental disorders
Pathogenesis
Potassium channels
Potassium channels (voltage-gated)
Seizures
Sodium channels
Sodium channels (voltage-gated)
Transcription factors
transcriptional regulation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Epilepsy is a common neurological disorder characterized by recurrent uncontrolled seizures and has an idiopathic " " etiology or a symptomatic " " component. Genetic studies have revealed that many epilepsy susceptibility genes encode ion channels, including voltage-gated sodium, potassium and calcium channels. The high prevalence of ion channels in epilepsy pathogenesis led to the causative concept of "ion channelopathies," which can be elicited by specific mutations in the coding or promoter regions of genes in epilepsies. Intriguingly, expression changes of the same ion channel genes by augmentation of specific transcription factors (TFs) early after an insult can underlie epilepsies. In this study, we review how the transcriptional regulation of ion channels in both and epilepsies can be controlled, and compare these epilepsy "ion channelopathies" with other neurodevelopmental disorders.
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2019.00587