New 1,4-Dienonesteroids from the Octocoral Dendronephthya sp

Two new steroids, dendronesterones D ( ) and E ( ), featuring with 1,4-dienone moiety, along with three known steroids, methyl 3-oxochola-4,22-diene-24-oate ( ), 5α,8α-epidioxy-24( )- methylcholesta-6,22-dien-3β-ol ( ), and 5α,8α-epidioxy-24( )-methylcholesta-6,9(11),22-trien-3β-ol ( ), were isolate...

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Bibliographic Details
Published in:Marine drugs 2019-09, Vol.17 (9), p.530
Main Authors: Huynh, Thanh-Hao, Chen, Pei-Chin, Yang, San-Nan, Lin, Feng-Yu, Su, Tung-Pin, Chen, Lo-Yun, Peng, Bo-Rong, Hu, Chiung-Chin, Chen, You-Ying, Wen, Zhi-Hong, Wu, Tung-Ying, Sung, Ping-Jyun
Format: Article
Language:English
Subjects:
Animals
Anthozoa - chemistry
anti-inflammatory
Anti-inflammatory agents
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - pharmacology
Carbon
Chromatography
Cytotoxicity
Dendronephthya
dendronesterone
Inflammation
iNOS
Lipopolysaccharides
Macrophages
Metabolites
Mice
Molecular Structure
Nitric Oxide Synthase Type II - antagonists & inhibitors
Nitric-oxide synthase
RAW 264.7 Cells
Spectrum analysis
steroid
Steroid hormones
Steroids
Steroids - isolation & purification
Steroids - pharmacology
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Summary:Two new steroids, dendronesterones D ( ) and E ( ), featuring with 1,4-dienone moiety, along with three known steroids, methyl 3-oxochola-4,22-diene-24-oate ( ), 5α,8α-epidioxy-24( )- methylcholesta-6,22-dien-3β-ol ( ), and 5α,8α-epidioxy-24( )-methylcholesta-6,9(11),22-trien-3β-ol ( ), were isolated from an octocoral sp. The structures of steroids and were elucidated by using spectroscopic methods and steroid was found to exhibit significant in vitro anti-inflammatory activity in lipopolysaccharides (LPS)-induced RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein.
ISSN:1660-3397
1660-3397
DOI:10.3390/md17090530