The effect of frailty on the 24‐hour blood pressure pattern in the very elderly

Frailty plays a crucial role in the management of hypertension in the very elderly and has a strong association with cardiovascular diseases. Nevertheless, its influence on the 24‐hour blood pressure pattern, including elevated asleep systolic blood pressure (BP) and the lack of BP fall during sleep...

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Bibliographic Details
Published in:The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2022-01, Vol.24 (1), p.67-73
Main Authors: Blauth, Fernando Gioppo, Vilar, Laís Araújo dos Santos, Pontes, Victor de Carvalho Brito, Moriguti, Júlio César, Ferriolli, Eduardo, Lima, Nereida Kilza da Costa
Format: Article
Language:English
Subjects:
Abdomen
Age
Aged
aged 80 and over
ambulatory blood pressure
Antihypertensives
Blood pressure
Blood Pressure - physiology
blood pressure dipping
Blood Pressure Monitoring, Ambulatory
Body mass index
Circadian Rhythm
Cross-Sectional Studies
Diabetes
Ethnicity
Exercise
Female
Frailty
Frailty - complications
Frailty - diagnosis
Frailty - epidemiology
Humans
Hypertension
Hypertension - complications
Hypertension - diagnosis
Hypertension - epidemiology
hypertension in the elderly
Male
Original
Orthostatic hypotension
Patients
Population
Questionnaires
Regression analysis
Variables
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Summary:Frailty plays a crucial role in the management of hypertension in the very elderly and has a strong association with cardiovascular diseases. Nevertheless, its influence on the 24‐hour blood pressure pattern, including elevated asleep systolic blood pressure (BP) and the lack of BP fall during sleep (non‐dipping) has not been explored in a population above 80 years. Patients older than 80 years were classified into frail or robust subtypes by the five item frailty phenotype criteria. All participants were submitted to office blood pressure measurements and ambulatory BP monitoring over a 24‐hour period. Nocturnal dipping was defined as nighttime BP fall ≥10%. Thirty‐eight frail and 36 non‐frail individuals (mean age 85.3 ± 3.7 years; 67% females) were analyzed. Awake systolic and diastolic BP were similar for frail and robust individuals. Frail patients had higher systolic BP during sleep (128 ± 15 mm Hg vs. 122 ±13 mm Hg p = .04) and reduced systolic BP fall [1 (‐4.5 – 5)% vs. 6.8 (2.1 – 12.8)% p 
ISSN:1524-6175
1751-7176
DOI:10.1111/jch.14409